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This study reports the results of our recent in vivo study using attenuation-based quantitative OCT for intra-operative mapping of brain cancer in patients. A total of 34 brain cancer patients were recruited, and an optimal optical attenuation threshold of 4.3 mm-1 was established with cancer of lower values. We achieved an excellent specificity of over 98%, with a corresponding sensitivity of over 95% for both high-grade and low-grade cancers. Applying the established optical attenuation threshold to infiltrated tissues, we were able to identify regions of cancers qualitatively matching the neuropathologist’s assessment. The study suggests that optical attenuation-based quantitative OCT represents a promising technology for intraoperative brain cancer detection and
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Hyeon-Cheol Park, Defu Chen, Wu Yuan, David W. Nauen, Kaisorn Chaichana, Chetan Bettegowda, Alfredo Quiñones-Hinojosa, Xingde Li, "Intraoperative detection of glioma infiltration with attenuation-based quantitative OCT," Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128302G (19 March 2024); https://doi.org/10.1117/12.3004223