Blood-mimicking dye phantoms for assessing photoacoustic oximetry accuracy

Zixin Wang; Keith A. Wear; Joshua Pfefer; Jesse V. Jokerst; William C. Vogt

doi:10.1117/12.3001708

13 March 2024 Blood-mimicking dye phantoms for assessing photoacoustic oximetry accuracy

Zixin Wang, Keith A. Wear, Joshua Pfefer, Jesse V. Jokerst, William C. Vogt

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284219 (2024) https://doi.org/10.1117/12.3001708
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photoacoustic imaging (PAI) is rapidly emerging for many clinical applications involving vascular mapping and tissue oximetry. Phantom-based evaluation of oximetry accuracy is invaluable for device evaluation but requires specialized equipment and use of potentially biohazardous blood. We developed stable, tunable blood-mimicking dye solutions that can simulate photoacoustic signals of blood at 750 nm and 850 nm for 40-100% SO2. We filled breast-mimicking polyacrylamide hydrogel phantoms with either dye solutions or deoxygenated bovine blood to test a custom PAI system. Results showed that the blood-mimicking dyes produced similar levels of SO2 accuracy in phantoms compared to blood samples, although some differences in sensitivity and root-mean-square difference were observed. These blood-mimicking dyes may offer a simpler, safer approach to evaluating oximetry measurement accuracy in PAI devices that could accelerate device evaluation and clinical translation.

Conference Presentation

Citation Download Citation

Zixin Wang, Keith A. Wear, Joshua Pfefer, Jesse V. Jokerst, and William C. Vogt "Blood-mimicking dye phantoms for assessing photoacoustic oximetry accuracy", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284219 (13 March 2024); https://doi.org/10.1117/12.3001708

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KEYWORDS

Dyes

Oximetry

Blood

Photoacoustic spectroscopy

Accuracy assessment

Biological samples

Safety

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