Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Chao Zhou; Regine Choe; Natasha S. Shah; Turgut Durduran; Guoqiang Yu; Amanda Durkin; David Hsiang; Rita Mehta; John A. Butler; Albert E. Cerussi; Bruce Jason Tromberg; Arjun G. Yodh

doi:10.1117/1.2798595

1 September 2007 Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Chao Zhou, Regine Choe, Natasha S. Shah, Turgut Durduran, Guoqiang Yu, Amanda Durkin, David Hsiang, Rita Mehta, John A. Butler, Albert E. Cerussi, Bruce Jason Tromberg, Arjun G. Yodh

Author Affiliations +

Journal of Biomedical Optics, Vol. 12, Issue 5, 051903 (September 2007). https://doi.org/10.1117/1.2798595

Abstract

We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb_T/N=69±21%), oxyhemoglobin (rctO₂Hb_T/N=73±25%), total hemoglobin (rctTHb_T/N=72±17%), and lipid concentration (rctLipid_T/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBF_T/N=75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Chao Zhou, Regine Choe, Natasha S. Shah, Turgut Durduran, Guoqiang Yu, Amanda Durkin, David Hsiang, Rita Mehta, John A. Butler, Albert E. Cerussi, Bruce Jason Tromberg, and Arjun G. Yodh "Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy," Journal of Biomedical Optics 12(5), 051903 (1 September 2007). https://doi.org/10.1117/1.2798595

Published: 1 September 2007

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY