CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 17 > Issue 10 > Article
Open Access
15 June 2012 Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models
Richard Su, Sergey A. Ermilov, Anton Liopo, Alexander A. Oraevsky
Author Affiliations +
Journal of Biomedical Optics, Vol. 17, Issue 10, 101506 (June 2012). https://doi.org/10.1117/1.JBO.17.10.101506
Abstract
We used a 3-D optoacoustic (OA) tomography system to create maps of optical absorbance of mice tissues contrasted with gold nanorods (GNRs). Nude mice were scanned before and after injection of GNRs at time periods varying from 1 to 192 h. Synthesized GNRs were purified from hexadecyltrimethylammonium bromide and coated with polyethylene glycol (PEG) to obtain GNR-PEG complexes suitable for in vivo applications. Intravenous administration of purified GNR-PEG complexes resulted in enhanced OA contrast of internal organs and blood vessels compared to the same mouse before injection of the contrast agent. Maximum enhancement of the OA images was observed 24 to 48 h postinjection, followed by a slow clearance trend for the remaining part of the studied period (eight days). We demonstrate that OA imaging with two laser wavelengths can be used for noninvasive, long-term studies of biological distribution of contrast agents.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
Citation Download Citation
Richard Su, Sergey A. Ermilov, Anton Liopo, and Alexander A. Oraevsky "Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models," Journal of Biomedical Optics 17(10), 101506 (15 June 2012). https://doi.org/10.1117/1.JBO.17.10.101506
Published: 15 June 2012
JOURNAL ARTICLE
 8 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 43 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Blood
3D image processing
Gold
Nanoparticles
Video
Image segmentation
Kidney
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top