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1 March 2016 Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue
Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, David Straton, Sharan D. Ramaswamy, Jessica C. Ramella-Roman
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Journal of Biomedical Optics, Vol. 21, Issue 7, 071109 (March 2016). https://doi.org/10.1117/1.JBO.21.7.071109
Abstract
Mueller matrix polarimetry and polarization-sensitive optical coherence tomography (PS-OCT) are two emerging techniques utilized in the assessment of tissue anisotropy. While PS-OCT can provide cross-sectional images of local tissue birefringence through its polarimetric sensitivity, Mueller matrix polarimetry can be used to measure bulk polarimetric properties such as depolarization, diattenuation, and retardance. To this day true quantification of PS-OCT data can be elusive, partly due to the reliance on inverse models for the characterization of tissue birefringence and the influence of instrumentation noise. Similarly for Mueller matrix polarimetry, calculation of retardance or depolarization may be influenced by tissue heterogeneities that could be monitored with PS-OCT. Here, we propose an instrument that combines Mueller matrix polarimetry and PS-OCT. Through the co-registration of the two systems, we aim at achieving a better understanding of both modalities.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, David Straton, Sharan D. Ramaswamy, and Jessica C. Ramella-Roman "Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue," Journal of Biomedical Optics 21(7), 071109 (1 March 2016). https://doi.org/10.1117/1.JBO.21.7.071109
Received: 19 October 2015; Accepted: 28 January 2016; Published: 1 March 2016
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KEYWORDS
Optical coherence tomography
Polarimetry
Birefringence
Tissue optics
Tissues
Polarization
Collagen
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