Myopia is a major cause of visual impairment worldwide. A reduction in scleral rigidity is hypothesized as an effective biomarker of degenerative myopia. However, no current technique is able to characterize posterior rigidity in-vivo and non-invasively. We present a novel methodology using phase-sensitive optical coherence tomography (PhS-OCT) to measure scleral rigidity. The rigidity is reflected by the magnitude of pulsatile fundus motion that is measured by PhS-OCT. A preliminary clinical experiment confirmed our methodology. Our findings can offer potential new diagnostic methods for degenerative myopia and related diseases, as well as applications for evaluating therapies that alter scleral mechanical properties.
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