Coupling of surface-enhanced Raman spectroscopy (SERS) with the coffee ring effect can overcome the poor reproducibility typically seen when using SERS. In this study, we developed a nitrocellulose membrane paper-based substrate for coffee ring enhanced SERS, which was highly hydrophobic and produced consistent coffee rings. After optimization of solution parameters including gold nanoparticle concentration and solvent, this platform demonstrated high enhancement and low variability using Malachite Green Isothiocyanate and Moraxella catarrhalis. This substrate has the potential to increase the usability and implementation of SERS by overcoming intrinsic limitations and is more accessible than current substrates.
The development of a real-time, non-invasive method for assessing hydration status is urgently needed in many communities such as the military and high-performance athletes. A probe-based spatially offset Raman spectroscopy system has been developed to accomplish this goal. Raman spectra, including the fingerprint and high wavenumber regions, have been collected from various tissue depths and superficial anatomical locations from collegiate athletes undergoing strength and conditioning regimens. Urine was collected alongside spectroscopy measurements to compare spectral information to urine specific gravity, a clinically relevant hydration metric. Water dynamics shown in spectral features are used to quantify hydration change during exercise regimens.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.