Mr. Changkui Guo Profile

Changkui Guo

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Proceedings Article | 29 December 2023 Paper

Ultraviolet photoacoustic microscope with enhanced DOF by liquid crystal modulation of light field

Zechen Wu, Changkui Guo, Cong Liu, Liu Liu, Wanlong Zhang, Wei Song

Proceedings Volume 12975, 129750F (2023) https://doi.org/10.1117/12.3015171

KEYWORDS: Liquid crystals, Ultraviolet radiation, Photoacoustic spectroscopy, Photoacoustic imaging, Modulation, Tissues, Image resolution, Phase distribution, Histopathology, Biomedical optics

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Ultraviolet photoacoustic imaging can detect the ultrasonic signals released by the cell nucleus through the strong absorption of ultraviolet light by DNA and RNA in organisms, which thus obtains images similar to those from traditional hematoxylin-eosin staining but no need of staining or sectioning. However, the traditional Optical-Resolution Photoacoustic Microscopy (OR-PAM) working in the ultraviolet band only maintains a micrometer-scale lateral resolution in a very limited depth range. Due to short Depth of Focus (DOF), the resolving capability of photoacoustic imaging deteriorates sharply, resulting in a severe degradation of image quality and adversely affecting the reliability of histopathologic diagnosis. Based on an extended Nijboer-Zernike (ENZ) theory of optical field regulation, a millimeter-level phase plate modulator of liquid crystal is designed to engineer the wavefront of ultraviolet photoacoustic illumination, achieving an increase in the DOF of the OR-PAM system at ~210 μm while maintaining a good lateral resolution of ~1.04 μm. This surpasses the traditional OR-PAM with Gaussian-mode excitation laser. The liquid crystal modulation is potentially valuable for obtaining non-destructive and label-free histology photoacoustic images of the cell nucleus.

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