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Chenchang Hu

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Proceedings Article | 29 November 2023 Poster

Subcellular tracking of deuterated drugs by stimulated Raman scattering microscopy

Chenchang Hu, Zexin Xue, Hyeon Jeong Lee

Proceedings Volume 12770, 127702J (2023) https://doi.org/10.1117/12.2687182

KEYWORDS: Raman scattering, Microscopy, Raman spectroscopy, Imaging systems, Yeast, Systems modeling, Plasma, Oxygen, Neurological disorders, Mitochondria

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Lipid peroxidation, linked to neurodegenerative diseases and mitochondrial dysfunction, targets polyunsaturated fatty acids (PUFAs) in cellular membranes. RT001, a novel drug with deuterium-substituted linoleic acid, inhibits lipid peroxidation by slowing down the chain reaction initiated by reactive oxygen species. Studies suggest that deuterated PUFAs presented in a fraction of the total PUFA pool, provide cellular protection. To gain insights into the underlying mechanisms, we utilized stimulated Raman scattering (SRS) imaging to analyze the subcellular distribution of RT001 using yeast as a model system. The isotopic substitution of deuterium enhances chemical contrast, enabling the observation of drug delivery dynamics. Concentration- and time-dependent aggregation of RT001 in lipid droplets and cell membranes were observed. SRS imaging holds promise for investigating metabolic processes of deuterated drugs such as RT001, thereby facilitating drug screening and development.

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