Dr. Cole Burks Profile

Dr. Cole Burks

at Univ of North Carolina at Chapel Hill

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Proceedings Article | 15 February 2021 Presentation + Paper

Preliminary in-vivo imaging evaluation of patient-specific scatter-corrected digital chest tomosynthesis

Christina Inscoe, Alex Billingsley, Connor Puett, A. Cole Burks, Otto Zhou, Jianping Lu, Yueh Lee

Proceedings Volume 11595, 1159524 (2021) https://doi.org/10.1117/12.2582206

KEYWORDS: In vivo imaging, Chest, Lung, Image quality, Computed tomography, Clinical trials, Reconstruction algorithms, Prototyping

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Purpose: Scatter reduction remains a challenge for chest tomosynthesis. The purpose of this study was to validate a lowdose patient-specific method of scatter correction in a large animal model and implement the technique in a human imaging study in a population with known lung lesions. Method: The porcine and human subjects were imaged with an experimental stationary digital chest tomosynthesis system. Full field projection images were acquired, as well as with a customized primary sampling device for sparse sampling of the primary signal. A primary sampling scatter correction algorithm was used to compute scatter from the primary beam information. Sparse scatter was interpolated and used to correct projections prior to reconstruction. Reconstruction image quality was evaluated over multiple acquisitions in the animal subject to quantify the impact of lung volume discrepancies between scans. Results: Variations in lung volume between the full field and primary sample projection images induced mild variation in computed scatter maps, due to acquisitions during separate breath holds. Reconstruction slice images from scatter corrected datasets including both similar and dissimilar breath holds were compared and found to have minimal differences. Initial human images are included. Conclusions: We have evaluated the prototype low-dose, patient-specific scatter correction in an in-vivo porcine model currently incorporated into a human imaging study. The PSSC technique was found to tolerate some lung volume variation between scans, as it has a minimal impact on reconstruction image quality. A human imaging study has been initiated and a reader comparison will determine clinical efficacy.

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