This study evaluated a multi-source cone beam computed tomography (ms-CBCT) design. The design replaces the single X-ray tube in the conventional CBCT with a linear array of collimated X-ray sources aligned along the axial direction. A single beam carbon nanotube (CNT) X-ray source with an adjustable external collimator was mechanically translated to different positions along the axial direction to simulate the configurations with different number of sources and corresponding beam cone angle. A flat panel detector was offset horizontally to extend the field of view. Several phantoms were scanned under different configurations for comparison. The scatter-primary-ratio was reduced essentially linearly with the increasing number of X-ray sources (ππ ππ’πππ) from 47% in the N1 (ππ ππ’πππ = 1, cone angle π = 10.3Β°) to below 20% in the N8 (ππ ππ’πππ = 8, cone angle π = 2.3Β°) configuration. The CT cupping artifact was reduced from 15% in N1 to 10% in N8. The nonuniformity of the CT numbers, as measured by the standard deviation of the Hounsfield Unit (HU) values from multiple regions of interest (ROIs) in the axial plane of a contrast phantom was reduced from 38.0 in the N1 to 19.8 in the N8 configuration. An anthropomorphic head phantom imaged with the N8 ms-CBCT configuration also has a more uniform line profile than the image with the N1 configuration in the central homogenous region.
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