Large area fractional laser treatment (LAFLT) is a new fat removal and weight loss concept, which applies microscopic thermal injuries to large parts of the skin. These injuries induce a controlled metabolic response which temporarily increases the energy expenditure (EE), thereby reducing overall weight. In a mouse model, we investigated the dosimetry settings to induce this metabolic reaction. Therefore, mice were housed in metabolic cages and their body composition was analyzed. Results showed a significant EE increase (31% - 91%, p < 0.05) over a 6-day period which seems to suggest that an enhanced metabolic state can be achieved.
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