The study of the interaction of fibronectin and phosphorylcholine molecules with surfaces is of high relevance to understand the biological performance of bioactive coatings. To accomplish this task, one-dimensional photonic crystals supporting Bloch surface waves were interrogated in label-free and enhanced fluorescence operation modes. In particular, the enhanced fluorescence mode offers the possibility to confirm the presence of proteins with a sharp improvement of the resolution. Bioactive coatings based on fibronectin/ phosphorylcholine have thus the potential to not only enhance the body acceptance of implanted devices, but also extend the lifetime of such devices.
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