Ms. Fei Yang Profile

Fei Yang

at South China Normal Univ

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Proceedings Article | 5 March 2021 Presentation + Paper

Photoacoustic small-animal microscopic imaging of monitoring photodynamic therapy

Fei Yang, Sihua Yang

Proceedings Volume 11643, 116430C (2021) https://doi.org/10.1117/12.2582651

KEYWORDS: Photoacoustic spectroscopy, Photodynamic therapy, Microscopes, Photoacoustic imaging, Tumors, Tissues, Optical imaging, Confocal microscopy, Blood vessels, Visualization

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The small-animal photoacoustic microscope can obtain microscopic imaging of small-animal tissues, and then quantitatively analyzes the blood vessel density, tumor distribution and treatment effect during photodynamic therapy. Through the different imaging modes of the depth-coded photoacoustic microscope, the three-dimensional structural information of the tumor tissue can be reconstructed. In this study, the small-animal photoacoustic microscope was used to quantitatively visualize the density, depth, and distribution of different specific absorbers during photodynamic therapy. This method successfully monitored the tumor's response during treatment, which indicates its good prospect in monitoring of photodynamic therapy. Overall, the small-animal photoacoustic microscope can dynamically monitor and evaluate the impact of photodynamic therapy on tumors, blood vessels, skin irritation and inflammation, etc. This is of great significance for the efficacy and safety evaluation of the development of therapeutic drugs. Therefore, the small-animal photoacoustic microscope has great potential in the biomedical research of basic biology.

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