Prof. François H. Guillemin Profile

Prof. François H. Guillemin

Directeur Général at Institut de Cancérologie de Lorraine

SPIE Involvement:

Author

Publications (37)

Proceedings Article | 20 March 2015 Paper

Robust bladder image registration by redefining data-term in total variational approach

Sharib Ali, Christian Daul, Ernest Galbrun, Marine Amouroux, François Guillemin, Walter Blondel

Proceedings Volume 9413, 94131H (2015) https://doi.org/10.1117/12.2077658

KEYWORDS: Bladder, Image registration, Cystoscopy, Motion estimation, Bladder cancer, Tumors, Algorithm development, Electroluminescent displays, Visualization, Motion models

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Proceedings Article | 17 June 2011 Paper

Bimodal spectroscopy for in vivo characterization of hypertrophic skin tissue: pre-clinical experimentation, spectral data selection and classification

Honghui Liu, Héloïse Gisquet, F. Guillemin, Walter C. P. Blondel

Proceedings Volume 8087, 80872H (2011) https://doi.org/10.1117/12.888926

KEYWORDS: Tissues, Spectroscopy, Tissue optics, Algorithm development, Skin, Ear, Feature extraction, Collagen, In vivo imaging, Luminescence

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Proceedings Article | 13 July 2009 Paper

Prevention of bladder tumor implantion after fluorescence-guided TUR with photodynamic therapy

Saoussen Berrahmoune, Lina Bezdetnaya, Peter de Witte, Agnès Leroux, Dominique Dumas, François Guillemin, Marie Ange D'Hallewin

Proceedings Volume 7380, 73801V (2009) https://doi.org/10.1117/12.828314

KEYWORDS: Tumors, Photodynamic therapy, Bladder, Luminescence, Bladder cancer, Control systems, Animal model studies, Fluorescence correlation spectroscopy, Tissues, Green fluorescent protein

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SPIE Journal Paper | 1 March 2009 Open Access

Monte Carlo modeling of multilayer phantoms with multiple fluorophores: simulation algorithm and experimental validation

Emilie Pery, Walter Blondel, Cedric Thomas, François Guillemin

JBO, Vol. 14, Issue 02, 024048, (March 2009) https://doi.org/10.1117/12.10.1117/1.3122368

KEYWORDS: Monte Carlo methods, Luminescence, Absorption, Tissues, Computer simulations, Algorithm development, Solids, Photon transport, Tissue optics, Scattering

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SPIE Journal Paper | 1 January 2009 Open Access

Classification of ultraviolet irradiated mouse skin histological stages by bimodal spectroscopy: multiple excitation autofluorescence and diffuse reflectance

Marine Amouroux, Gilberto Diaz Ayil, Walter Blondel, Genevieve Bourg-Heckly, Agnes Leroux, François Guillemin

JBO, Vol. 14, Issue 01, 014011, (January 2009) https://doi.org/10.1117/12.10.1117/1.3077194

KEYWORDS: Skin, Atrial fibrillation, Spectroscopy, Ultraviolet radiation, Selenium, Diagnostics, Optical fibers, Tissues, Cancer, Diffuse reflectance spectroscopy

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Proceedings Article | 20 July 2007 Paper

Diffuse reflectance spectroscopy's sensitivity to melanic layer thickness variations: an in vitro study on skin phantoms

Marine Amouroux, Gilberto Diaz, Emilie Péry, Walter Blondel, François Guillemin

Proceedings Volume 6628, 66280Y (2007) https://doi.org/10.1117/12.727851

KEYWORDS: Melanoma, Diffuse reflectance spectroscopy, Skin, In vitro testing, Monte Carlo methods, Absorption, Scattering, Numerical simulations, Tissue optics, Reflectivity

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Proceedings Article | 8 October 2005 Paper

In vitro characterization of gap junctional intercellular communication by gap-FRAP technique

M. Abbaci, J.-R. Stines, M. Barberi-Heyob, W. Blondel, D. Dumas, F. Guillemin, J. Didelon

Proceedings Volume 5859, 585909 (2005) https://doi.org/10.1117/12.632829

KEYWORDS: Luminescence, Cancer, In vitro testing, Proteins, Head, Neck, Confocal microscopy, Microscopes, Tissues, Monoclonal antibodies

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Proceedings Article | 15 April 2005 Paper

Spectral (optical) and mechanical responses of fresh and cryopreserved issued arteries

Emilie Pery, Walter Blondel, Jean-Christophe Goebel, Jacques Didelon, Francois Guillemin

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.588636

KEYWORDS: Arteries, Scattering, Tissues, Spectroscopes, Spectrometers, Tissue optics, Luminescence, Blood vessels, In vitro testing, Diffuse reflectance spectroscopy

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Cryopreservation is the only method for conserving blood vessels as future allografts with biological immunity controls. Although it affects vessels mechanical structure, no biomechanical integrity simple test is available today. Biological tissues optical properties characterization by spectroscopic methods is of interest due to their types or natures variations. Collected data complementarity contributes to "photodiagnosis" applicative prospects (cancer, vascular...). Pig carotid artery rings were tested after excision and after one month cryopreservation. An uniaxial mechanical testing device was used for ring stretching, and elongation and axial forces measurement. Circumferential large strains and stresses were calculated. Simultaneously, each artery ring optical characteristics was measured using fibered autofluorescence and elastic scattering spectrometers. Mechanical results showed nonlinear strain/stress curves and large deformations in good agreement with other referenced works. Significant differences (p<0.05) between fresh and cryopreserved rings mechanical properties were noticed. Elastic scattering spectra intensity variations were well correlated with artery mechanical properties. The standardized autofluorescence spectra were more clearly correlated with anatomo-histological changes due to cryopreservation, providing rather accurate differentiation between fresh and cryopreserved samples. This study offers a new perspective to detect changes of cryopreserved arterial samples mechanical properties. Coupling mechanical tests (uniaxial traction of arterial rings) and optical spectroscopic measurements (autofluorescence, elastic scattering) is the driving point: it allows correlating mechanical modifications and spectral variations of artery rings before and after cryopreservation. Ultimately, this new approach could help developping a device allowing non-invasive, atraumatic and contactless optical examinations of arterial graft to assess its mechanical state before reimplantation.

Proceedings Article | 1 September 2004 Paper

Discrimination between normal and cancerous cells by gap-FRAP: feasibility in endoscopy

Jean-Rene Stines, Dominique Dumas, Walter Blondel, Jacques Didelon, Francois Guillemin

Proceedings Volume 5459, (2004) https://doi.org/10.1117/12.545495

KEYWORDS: Luminescence, Microscopes, Endoscopy, CCD cameras, Confocal microscopy, Cancer, Microscopy, Molecules, Tissues, Tissue optics

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Proceedings Article | 8 October 2003 Paper

In vivo cancer diagnostics by space-resolved diffuse reflectance spectroscopy

Vadzim Chalau, Jacques Didelon, J. Istomin, Michael Samtsov, Eugeny Voropay, D. Wolf, Francoi Guillemin

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.499961

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Optical fibers, Light sources, In vivo imaging, Light emitting diodes, Visible radiation, Scattering, Reflectivity, Spectroscopy

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Proceedings Article | 2 November 2001 Paper

PSF identification applied to 3D fluorescence microscopy quantification

Alain Dieterlen, Marie-Pierre Gramain, Chengqi Xu, Francois Guillemin, Serge Jacquey

Proceedings Volume 4431, (2001) https://doi.org/10.1117/12.447403

KEYWORDS: Point spread functions, Luminescence, Deconvolution, Microscopy, 3D acquisition, 3D image processing, Monochromatic aberrations, Image processing, Data acquisition, Objectives

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Proceedings Article | 26 October 2001 Paper

Fluence rate effects in meta-tetra(hydroxyphenyl)chlorin (mTHPC) photosensitized HT29 multicell tumor spheroids: comparative study with Colo26 spheroids

Estelle Maugain, Stephanie Coutier, Lina Bezdetnaya, Sophie Marchal, Jean-Louis Merlin, Jacques Didelon, Francois Guillemin

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446517

KEYWORDS: Photodynamic therapy, Plating, Luminescence, Cell death, Tumors, Oxygen, Scanning electron microscopy, Mathematical modeling, Proteins, Tumor growth modeling

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Proceedings Article | 19 May 1998 Paper

Effect of antioxidants on PDT treatment of cultured tumor cells

Vladislava Melnikova, Lina Bezdetnaya, Irina Belitchenko, Alexander Potapenko, Jean-Louis Merlin, Francois Guillemin

Proceedings Volume 3247, (1998) https://doi.org/10.1117/12.308142

KEYWORDS: Photodynamic therapy, Tumors, Colon, Bioalcohols, Fluorescence correlation spectroscopy, Analog electronics, Sodium, Toxicity, Adaptive optics, Physics

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Proceedings Article | 29 December 1997 Paper

Autofluorescence spectroscopy of normal and pathological tissues of the bladder

Ousama A'Amar, Francois Guillemin, Henri Begorre, Edouard Yvroud

Proceedings Volume 3197, (1997) https://doi.org/10.1117/12.297948

KEYWORDS: Bladder, Luminescence, Tissues, In vivo imaging, Tumors, Spectroscopy, Absorption, Tissue optics, Optical filters, Modulation

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Proceedings Article | 29 December 1997 Paper

Evaluation of interacellular tamoxifen-induced fluorescence in tamoxifen-resistant human breast adenocarcinoma cells

Nathalie Bachmann, Muriel Barberi-Heyob, Marie-Pierre Gramain, Corinne Bour, Sophie Marchal, Robert Parache, Francois Guillemin, Jean-Louis Merlin

Proceedings Volume 3197, (1997) https://doi.org/10.1117/12.297980

KEYWORDS: Luminescence, Receptors, Resistance, Breast, Microscopy, Cancer, Tumors, Proteins, Fluorescence spectroscopy, Spectroscopy

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Proceedings Article | 29 December 1997 Paper

Fluorescence microscopy image deconvolution: application to anthracycline distribution in breast cancer cells

Marie-Pierre Gramain, Corinne Bour, Alain Chomik, Alain Dieterlen, Olivier Haeberle, Jean Jacques Meyer, Sophie Marchal, Jean-Louis Merlin, Francois Guillemin

Proceedings Volume 3197, (1997) https://doi.org/10.1117/12.297960

KEYWORDS: Deconvolution, Luminescence, Microscopy, Point spread functions, Image segmentation, Cameras, Image processing algorithms and systems, Breast cancer, Image analysis, Lawrencium

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Proceedings Article | 29 December 1997 Paper

UV-induced autofluorescence spectroscopy in Barrett's esophagus

Juan Padilla-Ybarra, Genevieve Bourg-Heckly, Ousama A'Amar, Jocelyne Blais, Jacques Etienne, Francois Guillemin

Proceedings Volume 3197, (1997) https://doi.org/10.1117/12.297950

KEYWORDS: Esophagus, Luminescence, Tissues, Spectroscopy, Tumors, Collagen, Endoscopy, Cancer, Ultraviolet radiation, Fiber optics sensors

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Proceedings Article | 18 August 1997 Paper

Gaussian analyzing model of tissue light-induced fluorescence for the detection of early cancers

Ousama A'Amar, Dominique Lignon, Henri Begorre, Francois Guillemin, Edouard Yvroud

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280293

KEYWORDS: Luminescence, Tissues, Tissue optics, Absorption, Tumor growth modeling, Optical properties, Tumors, Fluorescence spectroscopy, Cancer, Data modeling

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Proceedings Article | 8 May 1997 Paper

Increase in reactive oxygen species production and phagocytic activity of polymorphonuclear neutrophils stimulated by preirradiated hematoporphyrin-derivative solution

Vladislava Melnikova, Lina Bezdetnaya, Irina Belitchenko, Alla Kyagova, Pascal Colosetti, Alexander Potapenko, Francois Guillemin

Proceedings Volume 2972, (1997) https://doi.org/10.1117/12.273496

KEYWORDS: Latex, Chemiluminescence, Photodynamic therapy, Oxygen, Particles, Spectroscopy, Blood, Visible radiation, Absorption spectroscopy, Tungsten

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Proceedings Article | 8 May 1997 Paper

Measurement of the light dosimetry parameters in PDT: definition of a dedicated instrumentation

F. Jaffry, V. Louis, Yves Granjon, Francois Guillemin, Edouard Yvroud

Proceedings Volume 2972, (1997) https://doi.org/10.1117/12.273500

KEYWORDS: Tissues, Oxygen, Resistors, Tumors, Sensors, Photodynamic therapy, Optical testing, Signal attenuation, Tissue optics, Photodiodes

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Proceedings Article | 11 December 1996 Paper

Early diagnosis of cancers using fluorescence imaging of tissues

Kamila Khemis, Dominique Lignon, V. Louis, Edouard Yvroud, Francois Guillemin

Proceedings Volume 2927, (1996) https://doi.org/10.1117/12.260638

KEYWORDS: Luminescence, Tissues, Cancer, Argon ion lasers, Imaging systems, Xenon, Lamps, Molecules, Image processing, Tumors

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Proceedings Article | 4 December 1996 Paper

Intravesical dosimetry applied to laser positioning in photodynamic therapy

Guillaume Beslon, Philippe Ambroise, Bernard Heit, Jacques Bremont, Francois Guillemin

Proceedings Volume 2924, (1996) https://doi.org/10.1117/12.260782

KEYWORDS: Bladder, Surgery, Photodynamic therapy, Tumors, Sensors, Visual process modeling, Visualization, Spherical lenses, Laser therapeutics, Light

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Proceedings Article | 4 December 1996 Paper

In vivo photodynamic therapy with meso-tetra(m-hydroxyphenyl)chlorin (mTHPC): influence of light intensity and optimization of photodynamic efficiency

Hadjira Rezzoug, Ousama A'Amar, Muriel Barberi-Heyob, Jean-Louis Merlin, Francois Guillemin

Proceedings Volume 2924, (1996) https://doi.org/10.1117/12.260755

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, In vivo imaging, Tissues, Oxygen, Dye lasers, Blood circulation, Cancer, Fluorescence spectroscopy

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Proceedings Article | 5 April 1996 Paper

Autofluorescence spectroscopy of normal and malignant tissues: both in-vivo and ex-vivo measurements in the upper aero-digestive tract and lung tissues

Ousama A'Amar, Dominique Lignon, O. Menard, Henri Begorre, Francois Guillemin, Edouard Yvroud

Proceedings Volume 2679, (1996) https://doi.org/10.1117/12.237596

KEYWORDS: Tissues, Luminescence, In vivo imaging, Tongue, Tumors, Spectroscopy, Lung, Laser induced plasma spectroscopy, Fiber optics sensors, Fluorescence spectroscopy

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Proceedings Article | 2 April 1996 Paper

Diffusion and localization of hematoporphyrin derivative in the normal bladder wall of a pig and a rat after local administration

Jean Bisson, Dominique Notter, P. Labrude, C. Vigneron, Francois Guillemin

Proceedings Volume 2675, (1996) https://doi.org/10.1117/12.237534

KEYWORDS: Bladder, Luminescence, Diffusion, Control systems, Bladder cancer, Tumors, Microscopy, Photodynamic therapy, Biopsy, In vitro testing

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Proceedings Article | 31 January 1996 Paper

Chemical induction of skin tumors in hairless (Skh-1) mice in view of photochemotherapy

Edwidge Bossu, Robert Parache, Dominique Notter, C. Vigneron, Francois Guillemin

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230947

KEYWORDS: Tumors, Skin, Laser therapeutics, Cancer, Astatine, Chemical reactions, Oxygen, Chemical analysis, Macromolecules, Inflammation

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Proceedings Article | 31 January 1996 Paper

Cellular uptake kinetics and photodynamic activity of meso-tetrahydroxyphenylchlorin (mTHPC)

Hadjira Rezzoug, Jean-Louis Merlin, Nadia Zeghari, Dominique Lignon, Sophie Marchal, Carole Ramacci, Edouard Yvroud, Francois Guillemin

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230967

KEYWORDS: Luminescence, Proteins, Absorption, Photodynamic therapy, Flow cytometry, Tissues, Fluorescence correlation spectroscopy, Diffusion, Microscopy, Fetus

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Proceedings Article | 31 January 1996 Paper

Diffusion and localization of hematoporphyrin derivative in the normal bladder wall of pig and rat after local administration

Jean Bisson, Dominique Notter, P. Labrude, C. Vigneron, Francois Guillemin

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230946

KEYWORDS: Bladder, Diffusion, Luminescence, Photodynamic therapy, Tumors, Control systems, Bladder cancer, Microscopy, Biopsy, Visible radiation

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Proceedings Article | 31 January 1996 Paper

Can ultrasounds induce cytotoxicity in presence of hematoporphyrin derivative as photodynamic therapy?

Anne Meunier, Francois Guillemin, Jean-Louis Merlin, Karine Eikermann, Sabine Schmitt, Markus Stoss, Dieter Hopfel, Gerhard Barth, Lina Bolotina-Bezdetnaya

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230973

KEYWORDS: Luminescence, Ultrasonography, Cavitation, Photodynamic therapy, Transducers, Tumors, Cancer, Spectroscopy, In vitro testing, Oxygen

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Proceedings Article | 27 December 1995 Paper

Optical instrumentation suitable for a real-time dosimetry during photodynamic therapy

Francois Guillemin, Ousama A'Amar, Hadjira Rezzoug, Dominique Lignon, F. Jaffry, C. Abdulnour, Laure Muller, Edouard Yvroud, Jean-Louis Merlin, Yves Granjon, Lina Bolotina-Bezdetnaya, Nadia Zeghari, Kamila Khemis, Muriel Barberi-Heyob, Anne Meunier-Reynes, Alexander Potapenko, Dominique Notter, C. Vigneron

Proceedings Volume 2627, (1995) https://doi.org/10.1117/12.228879

KEYWORDS: Tumors, Tissue optics, Photodynamic therapy, Data modeling, Luminescence, Absorption, Oxygen, Tissues, Picosecond phenomena, Sensors

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Proceedings Article | 31 January 1995 Paper

New concept of light dosimetry in photodynamic therapy: the control by using an ARX modeling

Laure Muller, Charles Abdul-Nour, Yves Granjon, Francois Guillemin, Edouard Yvroud

Proceedings Volume 2326, (1995) https://doi.org/10.1117/12.200814

KEYWORDS: Tissue optics, Scattering, Sensors, Photodynamic therapy, Tumors, Absorption, Backscatter, In vivo imaging, Signal processing, Soft tissue optics

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Proceedings Article | 18 January 1995 Paper

Optical dosimetry in photodynamic therapy: determination of the effective penetration depth of light in tissue according to measurements in backscattering models

Charles Abdul-Nour, Laure Muller, Yves Granjon, Francois Guillemin, Edouard Yvroud

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199188

KEYWORDS: Backscatter, Tissue optics, Photodynamic therapy, Signal attenuation, Optical testing, Tissues, Radon, Optical fibers, Scattering, Tumors

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Proceedings Article | 12 January 1995 Paper

Fluorescence detection system using a krypton laser: application to cancer diagnosis in photodynamic therapy

Marie-Luce Diller, Yves Granjon, Francois Guillemin, Edouard Yvroud

Proceedings Volume 2325, (1995) https://doi.org/10.1117/12.199153

KEYWORDS: Luminescence, Tissues, Cancer, Tumors, Photodynamic therapy, Fluorescence spectroscopy, Optical filters, Cameras, Mirrors, Krypton ion lasers

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Proceedings Article | 12 January 1995 Paper

Quantum yields of photodegradation of protoporphyrin IX in solution: luminescent, spectrophotometric, and biological testing of photobleaching

Lina Bezdetnaya, Nadia Zeghari, Muriel Barberi-Heyob, Jean-Louis Merlin, Alexander Potapenko, Francois Guillemin

Proceedings Volume 2325, (1995) https://doi.org/10.1117/12.199151

KEYWORDS: Luminescence, Absorbance, Quantum efficiency, Photodynamic therapy, Fluorescence correlation spectroscopy, Cancer, Spectroscopy, Absorption, Biological research, Fetus

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Proceedings Article | 22 December 1994 Paper

Measurement of penetration of haematoporphyrin derivative (HpD) encapsulated in liposomes into normal skin of female hairless rats by a tape stripping technique

M. Fenaux, Dominique Notter, P. Labrude, C. Vigneron, Francois Guillemin

Proceedings Volume 2328, (1994) https://doi.org/10.1117/12.197499

KEYWORDS: Skin, Biopsy, Diffusion, Thin films, Sodium, Tumors, Neck, Adhesives, Luminescence, Calibration

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Proceedings Article | 18 June 1993 Paper

Photodynamic therapy: development of a treatment and dosimetry system adapted to superficial tumors of the bladder

Dominique Lignon, Y. Jaboin, D. Wolf, Anne Meunier-Reynes, Francois Guillemin

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146315

KEYWORDS: Bladder, Photodynamic therapy, Optical spheres, Tumor growth modeling, Light sources and illumination, Tumors, Sensors, Light, Tissues, Optical fibers

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Proceedings Article | 1 November 1991 Paper

Light dosimetry in vivo in interstitial photodynamic therapy of human tumors

Anne Reynes, Simon Diebold, Dominique Lignon, Yves Granjon, Francois Guillemin

Proceedings Volume 1525, (1991) https://doi.org/10.1117/12.48214

KEYWORDS: Photodynamic therapy, Tissues, Signal attenuation, In vivo imaging, Tumors, Light, Biomedical optics, Optical fibers, Tumor growth modeling, Optical testing

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Showing 5 of 37 publications

Conference Committee Involvement (1)

Therapeutic Laser Applications and Laser-Tissue Interactions

24 June 2003 | Munich, Germany

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