Dr. Kirpal S. Kohli Profile

Dr. Kirpal S. Kohli

at Fraser Valley Cancer Ctr

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Proceedings Article | 15 February 2011 Paper

Initial experiments with flexible conductive electrodes for potential applications in cancer tissue screening

Daehan Chung, Sam Seyfollahi, Ajit Khosla, Bonnie Gray, Ash Parameswaran, Ramani Ramaseshan, Kirpal Kohli

Proceedings Volume 7929, 79290Z (2011) https://doi.org/10.1117/12.875563

KEYWORDS: Electrodes, Tissues, Polymers, Nanoparticles, Cancer, Silver, Metals, Skin, Lithography, Polymethylmethacrylate

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We present initial results on the fabrication and testing of micropatternable conductive nanocomposite polymer (C-NCP) electrodes for tissue impedance measurements. We present these proof-of-concept results as a first step toward the realization of our goal: an improved Electrical Impedance Scanning (EIS) system, whereby tissue can be scanned for cancerous tissue and other anomalies using large arrays of highly flexible microfabricated electrodes. Previous limitations of existing EIS system are addressed by applying polymer based microelectromechanical system (MEMS) technology. In particular, we attempt to minimize mechanical skin contact issues through the use of highly compliant elastomeric polymers, and increase the spatial resolution of measurements through the development of microelectrodes that can be micropatterned into large, highly dense arrays. We accomplish these improvements through the development of C-NCP electrodes that employ silver nanoparticle fillers in an elastomer polymer base that can be easily patterned using conventional soft lithography techniques. These new electrodes are tested on conventional tissue phantoms that mimic the electrical characteristics of human tissue. We characterize the conductivity of the electrodes (average resistivity of 7x10^-5 ohm-m +/- 14.3% at 60 wt-% of silver nanoparticles), and further employ the electrodes for impedance characterization via Cole-Cole plots to show that measurements employing C-NCP electrodes are comparable to those obtained with normal macroscopic metal electrodes. We also demonstrate anomaly detection using our highly flexible Ag/AgCl C-NCP electrodes on a tissue phantom.

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