Dr. Martin E. Gosnell Profile

Dr. Martin E. Gosnell

at Univ of New South Wales

SPIE Involvement:

Author

Publications (11)

Proceedings Article | 5 March 2021 Poster

Reactive oxygen species (ROS) measurement using multispectral auto-fluorescence imaging technique: a real-time and label-free technology

Abbas Habibalahi, Mahdieh Dashtbani, Jared Campbell, Ayad Anwer, Saabah Mahbub, Martin Gosnell, Sonia Saad, Carol Pollock, Ewa Goldys

Proceedings Volume 11655, 116551O (2021) https://doi.org/10.1117/12.2582863

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Proceedings Article | 5 March 2021 Presentation

Quantitative label-free characterisation and discrimination of osteoarthritis and rheumatoid arthritis based on hyperspectral autofluorescence features

Saabah Mahbub, Jared Campbell, Florence Lees, Anna Guller, Martin Gosnell, Ayad Anwer, Tania Crotti, Mihir Wechalekar, Mark Hutchinson, Ewa Goldys

Proceedings Volume 11655, 116551I (2021) https://doi.org/10.1117/12.2578486

KEYWORDS: Arthritis, Hyperspectral imaging, Cartilage, Bone, Visualization, Tissues, Inflammation

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Proceedings Article | 13 March 2019 Presentation

Label-free multispectral imaging for biological research and medical diagnostics (Conference Presentation)

Ewa Goldys, Jared Campbell, Saabah Mahbub, Abbas Habibalahi, Ayad Anwer, Martin Gosnell

Proceedings Volume 10890, 108900F (2019) https://doi.org/10.1117/12.2509130

KEYWORDS: Multispectral imaging, Biological research, Medical diagnostics, Tissues, Mode conditioning cables, Cancer, Auto-fluorescence imaging, Luminescence, Oxygen, Molecular mechanisms

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Proceedings Article | 4 March 2019 Presentation

Non-invasive monitoring of functional state of articular cartilage tissue with label-free unsupervised hyperspectral imaging (Conference Presentation)

Saabah Mahbub, Anna Guller, Martin Gosnell, Ayad Anwer, Ewa Goldys

Proceedings Volume 10890, 108900D (2019) https://doi.org/10.1117/12.2510768

KEYWORDS: Cartilage, Tissues, Hyperspectral imaging, Collagen, Luminescence, Biological research, Stem cells, Multispectral imaging

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Degradation of cartilage, occurring in osteoarthritis and other conditions leads to pain and reduced mobility. Current treatments beyond anti-inflammatories include intra-articular injections of hyaluronan or preparations based on adult mesenchymal stem cells (MSC), the latter shown to aid cartilage regeneration which requires the assessment of the cartilage, best on a molecular level and in a minimally invasive way. However, the conventional methods are invasive, destroying and can only provide a snapshot of a tissue structure and functional state on a sample-by-sample basis, while the continuous monitoring and high-throughput assays require low-invasive biopsy-free approach. As a first step to address this problem, in current work, we explored the potential of label-free multispectral imaging of endogenous tissue fluorescence to characterise the molecular composition, structure and functional status of ex vivo healthy bovine and osteoarthritic (OA) human knee articular cartilage followed by monitoring the effects of experimental treatment of OA cartilage performed ex vivo. However, strong autofluorescence of collagens (especially from collagen type II, which is the structural backbone of collagen fibrils) from various cartilage layers presents a challenge, because this signal tends to overpower the fluorescence from chondrocytes. We have managed to use Robust Dependent Component Analysis (RoDECA) to observe the detailed metabolic information with a proper account of intrinsic cellular heterogeneity, which signifies the sophisticated quantitative biochemical analysis. This work reports on the “signatures” of the healthy articular cartilage for superficial and transitional layer, define the “healthy range” of each fluorophore’s abundance and localization of chondrocytes non-invasively as well as identify the changes of the signatures in OA cartilage of real patients and observe the reaction of the OA cartilage on 2 types of experimental treatments.

Proceedings Article | 14 March 2018 Presentation

A Multi-LED light source for Hyperspectral Imaging of cells and tissues (Conference Presentation)

Kashif Islam, Ewa Goldys, Martin Ploschner, Martin Gosnell

Proceedings Volume 10486, 104860I (2018) https://doi.org/10.1117/12.2281230

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Proceedings Article | 14 March 2018 Presentation

Label-free unsupervised hyperspectral analysis for regenerative treatments on various cartilage layers (Conference Presentation)

Saabah Mahbub, Martin Gosnell, Ayad Anwer, Ewa Goldys

Proceedings Volume 10497, 104970I (2018) https://doi.org/10.1117/12.2289864

KEYWORDS: Cartilage, Collagen, Stem cells, Therapeutics, Hyperspectral imaging, Tissues, Biological research, Tissue optics, Luminescence, Imaging spectroscopy

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Proceedings Article | 12 December 2016 Paper

Non-imaging Optics of multi-LED light source for hyperspectral imaging

Kashif Islam, Martin Gosnell, Martin Ploschner, Ayad Anwer, Ewa Goldys

Proceedings Volume 10013, 100132T (2016) https://doi.org/10.1117/12.2244670

KEYWORDS: Light emitting diodes, Nonimaging optics, Glasses, Mirrors, Light sources, Zerodur, Coating, Hyperspectral imaging, Ultraviolet radiation, Visible radiation

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Proceedings Article | 9 December 2016 Paper

Label-free assessment of endothelial cell metabolic state using autofluorescent microscopy

Benjamin Pullen, Tam Nguyen, Martin Gosnell, Ayad Anwer, Ewa Goldys, Stephen Nicholls, Peter Psaltis

Proceedings Volume 10013, 100133F (2016) https://doi.org/10.1117/12.2244642

KEYWORDS: Hyperspectral imaging, Microscopy, Mode conditioning cables, Tissue optics, In vivo imaging, Atrial fibrillation, In vitro testing, Signal detection, Nondestructive evaluation, Biomedical optics

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Proceedings Article | 9 December 2016 Paper

Hyperspectral imaging of endogenous fluorescent metabolic molecules to identify pain states in central nervous system tissue

Vasiliki Staikopoulos, Martin Gosnell, Ayad Anwer, Sanam Mustafa, Mark Hutchinson, Ewa Goldys

Proceedings Volume 10013, 1001306 (2016) https://doi.org/10.1117/12.2243158

KEYWORDS: Hyperspectral imaging, Tissues, Molecules, Injuries, Animal model studies, Nervous system, Data modeling, Image segmentation, Surgery, Nerve

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Proceedings Article | 17 May 2016 Presentation

Deconstructing autofluorescence: non-invasive detection and monitoring of biochemistry in cells and tissues (Conference Presentation)

Ewa Goldys, Martin Gosnell, Ayad Anwer, Juan Cassano, Carolyn Sue, Saabah Mahbub, Sandeep Pernichery, David Inglis, Partho Adhikary, Jalal Jazayeri, Michael Cahill, Sonia Saad, Carol Pollock, Melanie Sutton-Mcdowall, Jeremy Thompson

Proceedings Volume 9703, 97030R (2016) https://doi.org/10.1117/12.2212443

KEYWORDS: Tissues, Luminescence, Biochemistry, Multispectral imaging, Stem cells, Biology, Medicine, Image processing, Microscopes, Genetics

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