The ability to reproducibly and accurately control light matter interaction on the nanoscale is at the core of the field of
optical biosensing enabled by the engineering of nanophotonic and nanoplasmonic structures. Efficient schemes for
electromagnetic field localization and enhancement over precisely defined sub-wavelength spatial regions is essential to
truly benefit from these emerging technologies. In particular, the engineering of deterministic media without translational
invariance offers an almost unexplored potential for the manipulation of optical states with vastly tunable transport and
localization properties over broadband frequency spectra. In this paper, we discuss deterministic aperiodic plasmonic and
photonic nanostructures for optical biosensing applications based on fingerprinting Surface Enhanced Raman Scattering
(SERS) in metal nanoparticle arrays and engineered light scattering from nanostructured dielectric surfaces with low
refractive index (quartz).
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