Within this work we explore texture analysis of optical coherence tomography images and machine learning for automated detect classification of breast biopsies. Under an approved IRB protocol, breast biopsy specimens from 100 patients were imaged with a high resolution OCT system providing 3.7 micron axial resolution. The texture features extracted were first order statistics (histogram distribution) and second order statistics (such as GLCM). Binary classification was carried out for two cases: 1) risk 0 (no risk of cancer) versus everything else and 2) risk 3 (cancer) versus everything else.
Optical coherence tomography (OCT) is being studied to provide rapid biopsy evaluation. Here we developed a deep learning algorithm to rapidly identify disease in OCT images in an 87-patient IRB-approved clinical study. Pathologists labelled each biopsy into two categories: non-interest (no disease) and interest (for further pathological analysis). Our dataset was split by patients into training (n = 70) and validation (n = 17). The Resnet18 architecture used the Adam optimizer, had a learning rate of 0.01, batch size of 8, and ran for 30 epochs. The network achieved 97% training accuracy and 70% validation accuracy.
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