Mr. Patrick Schöps Profile

Patrick Schöps

at Fraunhofer IWS Dresden

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Proceedings Article | 5 March 2021 Presentation + Paper

PDMS-free modular plug and play construction kit for the development of micro-physiological systems

Stephan Behrens, Florian Schmieder, Christoph Polk, Patrick Schöps, Frank Sonntag

Proceedings Volume 11637, 116370O (2021) https://doi.org/10.1117/12.2585203

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Micro-physiological platforms (organ-on-chip, multi-organ-chip) have an enormous potential to strengthen research in drug development, toxicological screening, personalized medicine and disease modeling. The design of such microphysiological systems (MPS) is an interdisciplinary challenge. We designed a modular plug and play construction kit for the development of MPS. The modular system provides a large number of functional, miniaturized modules such as pumps, oxygenators, reservoirs and cell culture compartments whose fluidic interfaces comply with the luer-lock standard. This allows the modules to be combined quickly and easily with each other, according to the intended application. Depending on their functionality, the modules are implemented using the multilayer technology established at the IWS or modern 3D printing processes. The construction kit also provides a universal control platform. This consists of a basic controller for micro pumps and valves which can be combined with numerous additional modules like gas mixers, oxygenators and pH sensors. Thus, the financial and time expenditure of an MPS development can be drastically reduced with the help of the modular system.

Proceedings Article | 2 March 2020 Paper

Efficiency improvement of multilayer lab-on-a-chip production by dynamic beam shaping

Frank Sonntag, Thomas Kuntze, Patrick Schöps, Stephan Behrens, Florian Schmieder, Volker Franke, Udo Klotzbach

Proceedings Volume 11268, 112681C (2020) https://doi.org/10.1117/12.2542018

KEYWORDS: Mirrors, Scanners, Lab on a chip, Beam shaping, Control systems, Logic, Polymers, Interfaces, System on a chip, Laser processing

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Lab-on-a-Chip (LoC) systems are utilized for medicine and biotechnology applications. The field reaches from synthesis of active pharmaceutical ingredients up to the detection of specific biomarkers and the cultivation of human cells and human tissues for substance testing, personalized and regenerative medicine. LoC systems can be realized quickly and flexibly with an established closed technology chain developed at Fraunhofer IWS. In the first step, the system is constructively split into individual layers, which are later formed in each case by a separate foil. In the second step, a material with the desired properties is selected from the functional boundary conditions for each layer. In the third step, the foils are cut by means of laser micro-material processing, structured on both sides and optionally functionalized. In the fourth and final step, the individual foils are laminated together into a multilayer system using different technologies. In order to increase the effectiveness of laser micro-material processing, the established scanner-based optical design was further developed. The f-Theta lens was removed and replaced by a dynamic beam shaping element and a fixed focal length lens located in the beam path in advance of the scanner (“post-objective scanning”). As a high-dynamic beam shaping module, a mirror with piezo-driven surface curvature is used. The focal spot can be placed in a plane via a defined curvature as a function of the scanner mirror positions. By eliminating the f-Theta objective, the working area is increased by a factor of 4, resulting in a total process efficiency improvement.

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