Finding the components of an optical system that are most sensitive to misalignment allows a designer to insulate them from outside perturbations or incorporate compensators to account for alignment errors. At Advanced Optical Systems, Inc. (AOS) we used opto-mechanical constraint (OMC) equations to analyze the misalignment sensitivity of an optical correlator system and develop a better design. The OMC equations provide sensitivity coefficients for each element in the design that can be used to determine which components create the greatest image shift and focus errors when not optimally aligned. The OMC analysis model of the optical correlator was verified using a test bench with lenses in adjustable mounts to induce known amounts of misalignment in multiple axes. The experimental data matched the calculated values for each tested lens. The OMC coefficients assisted in identifying (1) lenses that are sensitive to loose manufacturing tolerances, (2) where subsystem designs can be beneficial, and (3) materials that provide optimum thermal performance. We will show results from our latest optical correlator package built using the OMC model analysis, which was critical to making decisions in the opto-mechanical design state of system development. We will also discuss a MATLAB simulation of AOS' optical correlator that incorporates the opto-mechanical constraints into a digital simulation of the correlation image.
Recent studies have indicated that polarized light may be useful in the discrimination between benign and malignant moles. In fact, imaging polarimetry could provide noninvasive diagnosis of a range of dermatological disease states. However, in order to design an efficacious sensor for clinical use, the complete polarization-altering properties of a particular disease must be well understood. We present Mueller matrix imaging polarimetry as a technique for characterizing various dermatological diseases. Preliminary Mueller matrix imagery at 633 nm suggests that both malignant moles and lupus lesions may be identified through polarimetric measurements. Malignant moles are found to be less depolarizing than the surrounding tissue, and lupus lesions are found to have rapidly varying retardance orientation.
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