This work focuses on the further development of the optical methods based on polarization detection to improve the reliability of the results of evaluation of structural changes in biological tissues. The paper presents an experimental study of tissues with pathological alterations to assess the capacity of differentiation of pathological conditions when using averaged local Mueller matrix elements. Experiments were carried out in direct scattering mode in histological samples of human epidermis. The practical significance of the results is the widespread application of the methodology for laser polarimetric analysis of structural changes in anisotropic tissues to identify and assess the degree of pathology in medical diagnosis of skin diseases.
The use of the polarimetry techniques for display and study of biological tissues has gained increasing interest in recent years. This interest is related mainly to the non-invasiveness, relatively low cost, and ease of application among other characteristics. However, for full use of these advantages, the calibration methods must ensure the minimization of the effects of uncertainties related to the optical element positioning and the noise in intensities measurements.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.