Dr. Steven L. Ponder Profile

Dr. Steven L. Ponder

Advanced Development Director

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Proceedings Article | 4 July 2000 Paper

Optical computed tomography for imaging the breast: first look

Richard Grable, Steven Ponder, Nikolaos Gkanatsios, William Dieckmann, Patrick Olivier, Robert Wake, Yueping Zeng

Proceedings Volume 4082, (2000) https://doi.org/10.1117/12.390556

KEYWORDS: Breast, Mammography, Computed tomography, Sensors, Breast imaging, Scanners, Imaging systems, Data acquisition, Magnetic resonance imaging, Optical tomography

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The purpose of the study is to compare computed tomography optical imaging with traditional breast imaging techniques. Images produced by computed tomography laser mammography (CTLM^TM) scanner are compared with images obtained from mammography, and in some cases ultrasound and/or magnetic resonance imaging (MRI). During the CTLM procedure, a near infrared laser irradiates the breast and an array of photodiodes detectors records light scattered through the breast tissue. The laser and detectors rotate synchronously around the breast to acquire a series of slice data along the coronal place. The procedure is performed without any breast compression or optical matching fluid. Cross-sectional slices of the breast are produced using a reconstruction algorithm. Reconstruction based on the diffusion theory is used to produce cross-sectional slices of the breast. Multiple slice images are combined to produce a three dimensional volumetric array of the imaged breast. This array is used to derive axial and sagittal images of the breast corresponding to cranio-caudal and medio-lateral images used in mammography. Over 200 women and 3 men have been scanned in clinical trials. The most obvious features seen in images produced by the optical tomography scanner are vascularization and significant lesions. Breast features caused by fibrocystic changes and cysts are less obvious. Breast density does not appear to be a significant factor in the quality of the image. We see correlation of the optical image structure with that seen with traditional breast imaging techniques. Further testing is being conducted to explore the sensitivity and specificity of optical tomography of the breast.

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