Prof. Syed Abrar A. Hasan Profile

Prof. Syed Abrar A. Hasan

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Publications (5)

SPIE Journal Paper | 21 July 2023 Open Access

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance

Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Shaista Siddiqui, Amjad P. Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen G. Bown, Rongguang Liang, Tayyaba Hasan, Jonathan P. Celli

JBO, Vol. 28, Issue 08, 082809, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.8.082809

KEYWORDS: Photodynamic therapy, Tissues, Image segmentation, Cancer, Oncology, Biomedical optics, Tumors, Imaging systems, Light emitting diodes, Collagen

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SignificanceIndia has one of the highest rates of oral squamous cell carcinoma (OSCC) in the world, with an incidence of 15 per 100,000 and more than 70,000 deaths per year. The problem is exacerbated by a lack of medical infrastructure and routine screening, especially in rural areas. New technologies for oral cancer detection and timely treatment at the point of care are urgently needed.AimOur study aimed to use a hand-held smartphone-coupled intraoral imaging device, previously investigated for autofluorescence (auto-FL) diagnostics adapted here for treatment guidance and monitoring photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence (FL).ApproachA total of 12 patients with 14 buccal mucosal lesions having moderately/well-differentiated micro-invasive OSCC lesions (<2 cm diameter and <5 mm depth) were systemically (in oral solution) administered three doses of 20 mg / kg ALA (total 60 mg / kg). Lesion site PpIX and auto-FL were imaged using the multichannel FL and polarized white-light oral cancer imaging probe before/after ALA administration and after light delivery (fractionated, total 100 J / cm2 of 635 nm red LED light).ResultsThe handheld device was conducive for access to lesion site images in the oral cavity. Segmentation of ratiometric images in which PpIX FL is mapped relative to auto-FL enabled improved demarcation of lesion boundaries relative to PpIX alone. A relative FL (R-value) threshold of 1.4 was found to segment lesion site PpIX production among the patients with mild to severe dysplasia malignancy. The segmented lesion size is well correlated with ultrasound findings. Lesions for which R-value was >1.65 at the time of treatment were associated with successful outcomes.ConclusionThese results indicate the utility of a low-cost, handheld intraoral imaging probe for image-guided PDT and treatment monitoring while also laying the groundwork for an integrated approach, combining cancer screening and treatment with the same hardware.

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Proceedings Article | 17 March 2023 Presentation

Integrating optical diagnostics and PDT: image guided treatment of oral lesions using a handheld multichannel fluorescence probe

Jonathan Celli, Shakir Khan, Rongguang Liang, Tayyaba Hasan, Bilal Hussain, Shahid Ali Siddiqui, Syed Hasan

Proceedings Volume PC12359, PC1235906 (2023) https://doi.org/10.1117/12.2672304

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Proceedings Article | 4 March 2022 Presentation + Paper

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for ALA PDT monitoring and guidance

Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Mayra BaptistaLopesTeix, Shaista Siddiqui, Amjad Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen Bown, Rongguang Liang, Tayyaba Hasan, Jonathan Celli

Proceedings Volume 11940, 1194004 (2022) https://doi.org/10.1117/12.2609956

KEYWORDS: Photodynamic therapy, Cancer, Image segmentation, Tissues, Oncology, Light emitting diodes, Imaging systems, Visualization

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Proceedings Article | 14 August 2019 Presentation

Interpretation of ultrasonography indicators of photodynamic therapy treatment response in early malignancy of buccal mucosa (Conference Presentation)

Shaista Siddiqui, Ibne Ahmed, Kafil Akhtar, Shahid Ali Siddiqui, M. A. Bilal Hussain, Shakir Khan, Srivalleesha Mallidi, Amjad P. Khan, Hui Liu, Filip Cuckov, Grant Rudd, Liam Daly, Colin Hopper, Stephen G. Bown, Satish C. Sharma, Syed Abrar Hasan, Jonathan P. Celli, Tayyaba Hasan, Paola Leon

Proceedings Volume 11070, 110703Y (2019) https://doi.org/10.1117/12.2525982

KEYWORDS: Photodynamic therapy, Ultrasonography, Biopsy, Cancer, Biological research, Light emitting diodes, Light sources, Inflammation

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Proceedings Article | 14 August 2019 Presentation

Design and evaluation of applicators for photodynamic therapy of oral cavity tumors in low resource settings (Conference Presentation)

Amjad P. Khan, Srivalleesha Mallidi, Hui Liu, Liam Daly, Grant Rudd, M. A. Bilal Hussain, Shakir Khan, Shahid A. Siddiqui, Syed A. Hasan, Kafil Akhtar, Shaista Siddiqui, Meredith August, Maria Troulis, Filip Cuckov, Jonathan P. Celli, Tayyaba Hasan

Proceedings Volume 11070, 11070BH (2019) https://doi.org/10.1117/12.2525860

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Therapeutics, Surgery, Oncology, Phototherapy, Biochemistry, Light sources, 3D acquisition

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