Glaucoma is a common cause of blindness. Wireless, continuous monitoring of intraocular pressure (IOP) is an
important, unsolved goal in managing glaucoma. An IOP monitoring system incorporated into a glaucoma drainage
implant (GDI) overcomes the design complexity associated with incorporating a similar system in a more confined space
within the eye. The device consists of a micro-electro-mechanical systems (MEMS) based capacitive pressure sensor
integrated with an inductor printed directly onto a polyimide printed circuit board (PCB). The device is designed to be
incorporated onto the external plate of a therapeutic GDI. The resonance frequency changes as a function of IOP, and is
tracked remotely using a spectrum analyzer. A theoretical model for the reader antenna was developed to enable
maximal inductive coupling with the IOP sensor implant. Pressure chamber tests indicate that the sensor implant has
adequate sensitivity in the IOP range with excellent reproducibility over time. Additionally, we show that sensor
sensitivity does not change significantly after encapsulation with polydimethylsiloxane (PDMS) to protect the device
from fluid environment. In vitro experiments showed that the signal measured wirelessly through sheep corneal and
scleral tissue was adequate indicating potential for using the system in human subjects.
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