Dr. Virginie Callot Profile

Dr. Virginie Callot

Ph.D. at National Institutes of Health

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Proceedings Article | 2 May 2003 Paper

IVIM-based MRI method to study the microcirculation in the heart: preliminary results in dogs

Virginie Callot, Eric Bennett, Han Wen

Proceedings Volume 5031, (2003) https://doi.org/10.1117/12.480284

KEYWORDS: Diffusion, Computer programming, Magnetic resonance imaging, Heart, In vivo imaging, Signal attenuation, Anisotropy, Capillaries, Blood circulation, Brain

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In living organs, microcirculation in the capillaries and high order branches can be seen as a macroscopically random process. The Intra Voxel Incoherent Motion (IVIM) method uses a diffusion-weighted magnetic resonance imaging sequence to register this pseudo-random motion. It is able to observe perfusion in addition to the brownian diffusion by its relatively large distance of movement. The dependence of the MR signal (S) on the diffusion weighting b can be approximated as a bi-exponential relation: (S/S₀)=(1-f).exp(-bD)+f.exp[-b(D+D*)], where S₀ is the signal intensity for b=0, f the vascular volume fraction, D the molecular diffusion coefficient and D* a flow index. This effect, largely investigated in the brain, has never been applied in the heart, where the diffusion-weighted sequence is highly sensitive to bulk motion. We have studied microcirculation in the canine heart in vivo, with a well-controlled cardiac and respiratory gating protocol that overcomes the bulk motion effects. We demonstrated that the IVIM effect could be applied in the myocardium. The IVIM parameters were found equal to D=1.26*10^-3 mm²/s, f=11.98%, D*=12.87*10^-3 mm²/s. Moreover, the microcirculation is directionally anisotropic. The preferred direction of capillaries/small vessels is aligned with the myofibers in mid-myocardium in the left ventricle.

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