Optical coherence tomography (OCT) allows for imaging of fine structures below the surface of tissue based on inherent contrast from heterogeneity of optical refractive index. A contrast agent may be used when intrinsic contrast of a target in the sample is not enough. We synthesize magnetically-responsive nanorods whose reflectivity can be modulated by the orientation of a magnetic field and demonstrate their use in background-free OCT imaging. Because normal tissue does not respond to switching magnetic field, the signal from nanorods can be isolated from tissue.
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