Microscope-integrated optical coherence tomography (MIOCT) is an emerging multimodal imaging technology in which live volumetric OCT (“4D-OCT”) is displayed simultaneous with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with many visual cues not available in microscopy, but it cannot serve as a replacement due to lack of color features. In this work, we demonstrate progress toward a unified solution by fusion of data from both modalities, guided by segmented 3D features, yielding a more efficient visualization combining important cues from both modalities.
Microscope-integrated optical coherence tomography (MIOCT) is an emerging multimodal imaging technology in which live volumetric OCT (“4D-OCT”) is displayed simultaneously with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with many visual cues not available in microscopy, but it cannot serve as a replacement due to lack of color features. In this work, we demonstrate progress toward a unified solution by fusion of data from both modalities, guided by segmented 3D features, yielding a more efficient visualization combining important cues from both modalities.
Ophthalmic microsurgery involves the manipulation of thin, semi-transparent structures and has traditionally been performed using stereoscopic microscopes that provide an en face view of the surgical field. However, new therapeutic interventions such as subretinal injections require precise tool placement and dosing that are difficult to determine from the traditional microscope view. Optical coherence tomography (OCT) provides micron scale cross-sectional imaging and has become a gold standard in clinical ophthalmology settings, but its use in surgery has been more limited. The high-speed 400 kHz intraoperative system presented here provides valuable image guidance and quantitative metrics for a variety of human surgeries.
Microscope-integrated optical coherence tomography (MIOCT) systems allow for 4D visualization of thin,
semi-transparent structures during ophthalmic microsurgery. While these visualizations have greatly
increased the information available to surgeons, new surgical techniques, such as subretinal injections of
gene therapies, would benefit from quantitative measurements of structures imaged using OCT. Calibration
of true scan dimensions in OCT is complicated by inter-patient ocular variability as well as poor control of
scanner-patient alignment. We introduce novel measurement techniques for calibration and de-warping of
OCT imagery which allows for accurate measurement of intraocular structures including subretinal
microinjection bleb volumes in the ocular posterior segment.
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