Dr. Xinyi Xu Profile

Dr. Xinyi Xu

at Xidian Univ

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Publications (2)

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Proceedings Article | 2 March 2022 Presentation + Paper

Feasibility demonstration of supercontinuum fiber laser-based coherent anti-Stokes Raman scattering microscopy

Jiaojiao Zhang, Nan Wang, Haoyu Wang, Wangting Zhou, Xinyi Xu, Qi Zeng, Xueli Chen

Proceedings Volume 11973, 1197307 (2022) https://doi.org/10.1117/12.2608358

KEYWORDS: Fiber lasers, Microscopes, Microscopy, Raman spectroscopy, Imaging systems

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Coherent anti-Stokes Raman scattering (CARS) microscopy enables the analysis of the chemical composition and distribution within living cells, biomolecules, or living organisms in a label-free manner. Compared with the traditional spontaneous Raman imaging technology, its advantages of high imaging sensitivity and resolution, fast imaging speed and strong signal intensity make it more popular in multiple disciplines. The available CARS microscopes are most adopted advanced crystal solid-state lasers, which are expensive, bulky, and sensitive to the environmental changes. Supercontinuum fiber lasers with a wide spectral tuning range are increasingly used in biomedical applications due to their low cost, small size, and low environmental impact. Here, we homebuilt a CARS microscope based on a supercontinuum fiber laser, a specially tailored laser with a dual-channel time-synchronous outputs. The influence factors were investigated including the objective numerical aperture, laser power, and sample concentration, etc. The feasibility of CARS microscope was then verified by imaging the polystyrene microspheres (PS) and polymethyl methacrylate microspheres (PMMA). Finally, we imaged the lipid droplet distribution of EC109 cell, which revealed the application potential of the supercontinuum fiber laser-based CARS microscope in biomedical applications.

Proceedings Article | 5 March 2021 Presentation + Paper

Drug detection in different pharmaceutical dosage forms with Bessel beam-based Raman spectroscopy

Nan Wang, Feng Ren, Xu Nie, Xinyi Xu, Qi Zeng, Yonghua Zhan, Shouping Zhu, Xueli Chen

Proceedings Volume 11656, 116561H (2021) https://doi.org/10.1117/12.2578262

KEYWORDS: Raman spectroscopy, Remote sensing, Gaussian beams, Chemical analysis, Bessel beams, Analytical research, Tablets, Stomach, Skin, Signal to noise ratio

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To meet the diversity needs of diagnosis, treatment or prevention of diseases, different pharmaceutical dosage forms are designed and manufactured. The main role of each dosage form is drug carrier. However, changing forms might have some other different effects in clinical usages. For example, the capsule and tablets are absorbed by the intestine and stomach respectively, solutions and patches can act directly on the surface of skin etc. The quantity and quality analysis of the main drug in different form is a key issue in quality control. Therefore, it is a meaningful research of developing a facility method to detect the drug in different dosage forms. The traditional drug detection methods principally analyze and evaluate the performance through chemical reactions, photo-electricity or electrophoresis. However, these methods will cause damage to the samples. Owing to the non-invasive, non-destructive and label-free characteristics, Raman spectroscopy (RS) technique plays an important role in different fields. The current RS setup uses Gaussian beam as the excitation light, which can provide higher signal-to-noise in the thin or transparent sample. However, the Gaussian beam dispersed rapidly in the scattering medium, it is not conducive to in vivo or deep imaging. The Bessel beam having long focusing characteristics and self-reconstructing properties may provide solution to this problem. We here presented a new scheme for RS, which used a Bessel beam as the excitation light. The feasibility and effectiveness of the proposed scheme for detecting the drug in different pharmaceutical dosage forms were verified by series experiments.

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