Diabetic retinopathy, a slow progressive complication of diabetes, is the leading cause of vision impairment and blindness among working-age adults. In the presence of hyperglycemia, ocular tissues become stiffer in response to the increased non-enzymatic cross-linking of collagen fibrils. Ocular rigidity may serve as a cumulative response indicator of hyperglycemia. We have implemented an in vivo approach to estimate ocular rigidity using dynamic optical coherence tomography, which allowed us to investigate the diabetic retinopathy-associated biomechanical changes in a clinical setting.
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