A rapid, portable, and cost-effective method to detect the infection of SARS-CoV-2 is fundamental toward mitigating the current COVID-19 pandemic. A localized surface plasmon resonance (LSPR) sensor based on human angiotensin converting enzyme 2 protein (ACE2) functionalized silver nanotriangle array is developed for rapid coronavirus detection. The sensor is validated by SARS-CoV-2 spike RBD protein and CoV NL63 virus with high sensitivity and specificity. A linear shift of the LSPR wavelength and transmission intensity at a fixed wavelength (750 nm) versus the logarithm of the concentration of the spike RBD protein and CoV NL63 is observed. The limits of detection for the spike RBD protein, CoV NL63 in untreated saliva are determined to be 0.38 pM, and 625 PFU/mL, respectively, while the detection time is found to be less than 20 min. Such a LSPR sensor could serve as a potential rapid point-of-care diagnostic platform for COVID-19.
Spider silks are expected to become biocompatible and bioresorbable optical fibers, which can be utilized to transfer localized optical energy for various biomedical applications such as optical therapy and optical imaging inside living tissue. In this study, the optical properties of eco-friendly native spider silk as an efficient optical fiber have been demonstrated experimentally. The metal shells on the surface of silk fibers are fabricated by using glancing angle deposition technique. Lightwaves with broadband wavelengths are coupled into the silk fibers by direct incorporation of conventional optical fibers. The measurement results show the transmission loss of approximately 2 dB/cm. The optical performances of silk-based core-shell fiber combine with the biocompatibility, bioresorbability, flexibility, and tensile strength. The silk-based core-shell fibers are capable of delivering optical power through biological tissue for biophotonic purposes.
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