Ms. Yuting Ling Profile

Yuting Ling

Doctoral Candidate at Univ of Dundee

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Publications (5)

Proceedings Article | 21 February 2019 Paper

Evaluation of human corneal ulcer healing process using optical coherence tomography: an in vitro study

Yuting Ling, Chunhui Li, Christine Purslow, Ying Yang, Zhihong Huang

Proceedings Volume 10880, 108801H (2019) https://doi.org/10.1117/12.2509486

KEYWORDS: Tissues, Wound healing, 3D modeling, Optical coherence tomography, Cornea, In vitro testing, Collagen, Injuries, Animal model studies, Eye models

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Proceedings Article | 19 February 2018 Presentation + Paper

Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography

Kairui Feng, Kanheng Zhou, Yuting Ling, Paul O'Mahoney, Eadie Ewan, Sally Ibbotson, Chunhui Li, Zhihong Huang

Proceedings Volume 10496, 104960H (2018) https://doi.org/10.1117/12.2288492

KEYWORDS: Skin, Laser therapeutics, Optical coherence tomography, Laser energy, Laser irradiation, 3D image processing, In vitro testing, Laser optics, Imaging systems, Light scattering

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Proceedings Article | 7 February 2018 Presentation + Paper

Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

Yuting Ling, Chunhui Li, Kanheng Zhou, Guangying Guan, Stephen Lang, David McGloin, Ghulam Nabi, Zhihong Huang

Proceedings Volume 10468, 104680A (2018) https://doi.org/10.1117/12.2288485

KEYWORDS: Prostate cancer, Biopsy, Prostate, Elastography, Optical coherence tomography

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Proceedings Article | 2 March 2015 Paper

Optical coherence elastography (OCE) as a method for identifying benign and malignant prostate biopsies

Chunhui Li, Guangying Guan, Yuting Ling, Stephen Lang, Ruikang Wang, Zhihong Huang, Ghulam Nabi

Proceedings Volume 9312, 93122S (2015) https://doi.org/10.1117/12.2075711

KEYWORDS: Prostate, Biopsy, Tissues, Elastography, Prostate cancer, Cancer, Optical coherence tomography, Principal component analysis, Coherence (optics), Image resolution

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Objectives. Prostate cancer is the most frequently diagnosed malignancy in men. Digital rectal examination (DRE) - a known clinical tool based on alteration in the mechanical properties of tissues due to cancer has traditionally been used for screening prostate cancer. Essentially, DRE estimates relative stiffness of cancerous and normal prostate tissue. Optical coherence elastography (OCE) are new optical imaging techniques capable of providing cross-sectional imaging of tissue microstructure as well as elastogram in vivo and in real time. In this preliminary study, OCE was used in the setting of the human prostate biopsies ex vivo, and the images acquired were compared with those obtained using standard histopathologic methods. Methods. 120 prostate biopsies were obtained by TRUS guided needle biopsy procedures from 9 patients with clinically suspected cancer of the prostate. The biopsies were approximately 0.8mm in diameter and 12mm in length, and prepared in Formalin solution. Quantitative assessment of biopsy samples using OCE was obtained in kilopascals (kPa) before histopathologic evaluation. The results obtained from OCE and standard histopathologic evaluation were compared provided the cross-validation. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE (histopathology was a reference standard). Results. OCE could provide quantitative elasticity properties of prostate biopsies within benign prostate tissue, prostatic intraepithelial neoplasia, atypical hyperplasia and malignant prostate cancer. Data analysed showed that the sensitivity and specificity of OCE for PCa detection were 1 and 0.91, respectively. PCa had significantly higher stiffness values compared to benign tissues, with a trend of increasing in stiffness with increasing of malignancy. Conclusions. Using OCE, microscopic resolution elastogram is promising in diagnosis of human prostatic diseases. Further studies using this technique to improve the detection and staging of malignant cancer of the prostate are ongoing.

SPIE Journal Paper | 5 November 2013 Open Access

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

Guangying Guan, Chunhui Li, Yuting Ling, Ying Yang, Jan Vorstius, Robert Keatch, Ruikang Wang, Zhihong Huang

JBO, Vol. 18, Issue 11, 111417, (November 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.111417

KEYWORDS: Elastography, Optical coherence tomography, Acoustics, Tissues, Magnesium, Biomedical optics, Coherence (optics), Signal detection, Collagen, Ultrasonography

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