Recently, X-ray-induced acoustic computed tomography (XACT) has been raised as a promising imaging modality that can monitor the dose delivery in radiation therapy by combining high x-ray absorption contrast with the 3D propagation advantages provided by high-resolution ultrasound waves. k-Wave toolbox is a powerful MATLAB toolbox that can simulate the generation, propagation, and detection of the thermal acoustic wave. The purpose of this study was to summarize the k-Wave simulation works on XACT imaging. In our group, two simulation experiments were carried out, focusing on determining the radiation dose in stereotactic partial breast irradiation (SPBI) therapy and prostate radiation therapy, respectively. The simulation results demonstrated that the k-Wave simulation tool has great potential in simulating wave propagation and reconstructing XACT dose images according to initial pressure distribution.
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