Oropharyngeal squamous cell carcinoma (OPSCC) which refers to the cancer of the back of the throat, including the base of tongue and tonsils, has rapidly increased the past several decades and if undiagnosed, the tumors metastasize leading to many complications and decreased survival. In this study, Raman spectroscopy (RS) in combination with data classification algorithms was used to examine tonsil specimens (normal, benign, and malignant) to determine if RS could serve as a viable tool for real-time sensitive detection of OPSCC and ultimately other HPV-linked cancers.
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