Evaluation of the synergistic effect of tamoxifen and HSP70 inhibitor on breast cancer cells based on optical metabolic imaging

Biying Yu; Liqin Zheng; Xiaoman Zhang; Hui Li

doi:10.1117/12.2547773

20 December 2019 Evaluation of the synergistic effect of tamoxifen and HSP70 inhibitor on breast cancer cells based on optical metabolic imaging

Biying Yu, Liqin Zheng, Xiaoman Zhang, Hui Li

Author Affiliations +

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 1120921 (2019) https://doi.org/10.1117/12.2547773
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

Nicotinamide adenine dinucleotide (NADH) and Flavin adenine dinucleotide (FAD) are the endogenous fluorophores in cells. Optical redox ratio determined by the ratio of NADH and FAD was an important oxygenic indicator to reflect cell metabolism. Heat shock protein 70 (HSP70) has been recognized as a target for antitumor therapy. In this study, the optical redox ratio was used to evaluate the metabolic changes after the synergistic treatment of tamoxifen and HSP70 inhibitor in MCF-7 breast cancer cells based on optical metabolic imaging. In addition, the cell viability was also measured after the treatments of tamoxifen and HSP70 inhibitor by MTT assay. We observed that changes of the redox ratio and the cell viability with synergistic treatment of tamoxifen and HSP70 inhibitor were more obvious than the results of the sole treatment of tamoxifen or HSP70 inhibitor. These results indicated that the inhibition of HSP70 improve drug response of MCF-7 breast cancer cells.

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Biying Yu, Liqin Zheng, Xiaoman Zhang, and Hui Li "Evaluation of the synergistic effect of tamoxifen and HSP70 inhibitor on breast cancer cells based on optical metabolic imaging", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 1120921 (20 December 2019); https://doi.org/10.1117/12.2547773

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KEYWORDS

Breast cancer

Luminescence

Optical imaging

Glasses

Mode conditioning cables

Two photon imaging

Carbon dioxide

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