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3 October 2022 High-speed live cell interferometry for functional drug sensitivity screening of bioprinted tumor organoids (Conference Presentation)
Bowen Wang, Peyton J. Tebon, Alexander L. Markowitz, Graeme F. Murray, Huyen Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Alice Soragni, Michael A. Teitell
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Proceedings Volume 12223, Interferometry XXI; 122230C (2022) https://doi.org/10.1117/12.2632405
Event: SPIE Optical Engineering + Applications, 2022, San Diego, California, United States
Abstract
As interest grows in using three-dimensional (3D) tumor organoids as models for drug discovery and precision medicine, platforms for the reliable functional testing and analysis of these organoids are needed. Our group previously developed high-speed live cell interferometry (HSLCI), a powerful high-throughput functional drug screening platform which employs automated, repeated quantitative phase imaging (QPI) to longitudinally track drug-induced changes in biomass accumulation dynamics over time. Here, we present a method for the automated bioprinting of 3D tumor organoids coupled with real-time, highly parallel biomass quantification using HSLCI, and demonstrate its utility for drug screening.
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© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Bowen Wang, Peyton J. Tebon, Alexander L. Markowitz, Graeme F. Murray, Huyen Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Alice Soragni, and Michael A. Teitell "High-speed live cell interferometry for functional drug sensitivity screening of bioprinted tumor organoids (Conference Presentation)", Proc. SPIE 12223, Interferometry XXI, 122230C (3 October 2022); https://doi.org/10.1117/12.2632405
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KEYWORDS
Tumors
Interferometry
Medicine
3D modeling
Phase imaging
Resistance
Temporal resolution
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