Accurate pre-malignancy diagnosis of cervical tissue through fluorescence Mueller matrix imaging

Sumedha Chanda; Nishkarsh Kumar; Asima Pradhan

doi:10.1117/12.2669848

11 May 2023 Accurate pre-malignancy diagnosis of cervical tissue through fluorescence Mueller matrix imaging

Sumedha Chanda, Nishkarsh Kumar, Asima Pradhan

Proceedings Volume 12638, Women in Optics and Photonics in India 2022; 126380C (2023) https://doi.org/10.1117/12.2669848
Event: Women in Optics and Photonics in India, 2022, Bangalore, India

Conference Poster

Abstract

Mueller matrix polarimetry has the potential to diagnose different stages of pre-cancer utilizing elastic and in-elastically scattered signals from the human biological tissues. Absorption, scattering and emission of a beam, when traveling through a medium, manifest through diattenuation, polarizance and retardance, which are efficiently separated by the polar decomposition technique. The intrinsic fluorophores present in tissue imprint their characteristic signatures, reflecting corresponding changes in the dipole orientations. The Fluorescence Mueller matrix (FMM) is ideally suited to extract this information through the parameters diattenuation and polarizance, as the fluorescence adds extra depolarization and phase changes due to absorption and subsequent emission of light by tissue samples. Hence, our approach can potentially provide better results due to an enhancement in these parameters compared to only elastic scattering for diagnosing cancerous tissue.

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Sumedha Chanda, Nishkarsh Kumar, and Asima Pradhan "Accurate pre-malignancy diagnosis of cervical tissue through fluorescence Mueller matrix imaging", Proc. SPIE 12638, Women in Optics and Photonics in India 2022, 126380C (11 May 2023); https://doi.org/10.1117/12.2669848

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