Tumor-specific fluorescent contrast agents

Samuel I. Achilefu; Richard B. Dorshow; Joseph E. Bugaj; Raghavan Rajagopalan

doi:10.1117/12.382718

19 April 2000 Tumor-specific fluorescent contrast agents

Samuel I. Achilefu, Richard B. Dorshow, Joseph E. Bugaj, Raghavan Rajagopalan

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382718
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Several dyes are currently used for various biomedical applications due to their biocompatibility and high molar absorptivity. Localization of dyes in tumors may be mediated by several factors such as leaky vasculature and high metabolic activity in proliferating cells. However, these mechanisms of action make it difficult to differentiate inflammation from benign or malignant tumors. In order to enhance their tumor specificity, dyes have been conjugated to biomolecules that target unique factors in various diseased state. However, such large biomolecules can elicit adverse immunogenic reactions in humans, and are often preferentially taken up by the liver. Furthermore, for solid tumors which may rely on diffusion of the biomarkers from the vascular, penetration of large dye conjugates is not favorable. To overcome these problems, we designed and synthesized novel dye-peptide conjugates that are receptor specific. The efficacy of these new fluorescent contrast agents was tested in vivo in well-characterized rat tumor lines. The resulting optical images demonstrate that successful specific tumor targeting was achieved.

Citation Download Citation

Samuel I. Achilefu, Richard B. Dorshow, Joseph E. Bugaj, and Raghavan Rajagopalan "Tumor-specific fluorescent contrast agents", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382718

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