Dr. Richard B. Dorshow Profile

Dr. Richard B. Dorshow

Chief Scientific Officer at MediBeacon Inc

SPIE Involvement:

Author

Publications (31)

Proceedings Article | 17 March 2023 Presentation + Paper

Clinical results from a pilot multi-center study using a novel fluorescent tracer agent for renal function measurement

Richard Dorshow, Jeng-Jong Shieh, Martin Debreczeny

Proceedings Volume 12398, 1239803 (2023) https://doi.org/10.1117/12.2648541

KEYWORDS: Skin, Plasma, Fluorescence intensity, Fluorescence, Point-of-care devices, Kidney, Data acquisition, Biological samples, Signal processing, Data conversion

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Proceedings Article | 7 March 2019 Paper

Noninvasive point-of-care measurement of gastrointestinal permeability

Richard Dorshow, J. Johnson, Martin Debreczeny, I. Rochelle Riley, Jeng-Jong Shieh, Thomas Rogers, Carla Hall-Moore, Nurmohammad Shaikh, Phillip Tarr

Proceedings Volume 10893, 1089307 (2019) https://doi.org/10.1117/12.2507965

KEYWORDS: Fluorescent markers, Skin optics, Luminescence, Point-of-care devices, Absorption, Fluorescence spectroscopy, Calibration

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SPIE Journal Paper | 11 May 2018 Open Access

Transdermal optical renal function monitoring in humans: development, verification, and validation of a prototype device

Martin Debreczeny, Richard Dorshow

JBO, Vol. 23, Issue 05, 057003, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.057003

KEYWORDS: Luminescence, Sensors, Kidney, Ear, Skin, Prototyping, Signal to noise ratio, Scattering, In vivo imaging, In vitro testing

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Proceedings Article | 21 February 2017 Presentation + Paper

Modeling of transdermal fluorescence measurements from first-in-human clinical trials for renal function determination using fluorescent tracer agent MB-102

Kimberly Shultz, Martin Debreczeny, Richard Dorshow, Jennifer Keating, Kate Bechtel

Proceedings Volume 10079, 100790I (2017) https://doi.org/10.1117/12.2251068

KEYWORDS: Monte Carlo methods, Kidney, Signal detection, Tissue optics, Fluorescence spectroscopy, Mathematical modeling, Instrument modeling, Diffusion, Skin, Blood, Optical properties, Scattering, Light

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Proceedings Article | 21 February 2017 Presentation + Paper

Development and clinical trial results of a prototype device for trans-cutaneous monitoring of kidney function

Martin Debreczeny, Richard Dorshow

Proceedings Volume 10079, 100790K (2017) https://doi.org/10.1117/12.2250975

KEYWORDS: Kidney, Luminescence, Skin, Blood, Signal to noise ratio, Clinical trials, Prototyping, Medical device development, Plasma, Light emitting diodes, Sensors

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Proceedings Article | 22 April 2016 Paper

Application of fluorescent tracer agent technology to point-of-care gastrointestinal permeability measurement

Richard Dorshow, Jeng-Jong Shieh, Thomas Rogers, Carla Hall-Moore, Nurmohammad Shaikh, Michael Talcott, Phillip Tarr

Proceedings Volume 9723, 97230A (2016) https://doi.org/10.1117/12.2211790

KEYWORDS: Point-of-care devices, In vivo imaging, Optical testing, Diagnostics, Kidney, In vitro testing, Nanomaterials, Fluorescent markers, Luminescence, Statistical analysis, Medicine, Absorption, Animal model studies, Eye, Target detection

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Proceedings Article | 12 March 2015 Paper

Results of the first-in-human clinical trial for MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate

Richard Dorshow, Martin Debreczeny, Thomas Dowling

Proceedings Volume 9339, 933906 (2015) https://doi.org/10.1117/12.2078346

KEYWORDS: Clinical trials, Plasma, Blood, Kidney, Toxicity, Data modeling, In vivo imaging, Animal model studies, Injuries, Safety

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Proceedings Article | 5 March 2014 Paper

Initial formal toxicity evaluation of APC-2, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate in preparation for a first-in-man clinical trial

Joseph Bugaj, Richard Dorshow

Proceedings Volume 8956, 89560I (2014) https://doi.org/10.1117/12.2039881

KEYWORDS: Toxicity, Blood, Plasma, Safety, Skin, Pharmacology, Vehicle control, Clinical trials, Pathology, Electrocardiography

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Proceedings Article | 21 February 2013 Paper

Real-time point-of-care measurement of impaired renal function in a rat acute injury model employing exogenous fluorescent tracer agents

Richard Dorshow, Richard Fitch, Karen Galen, Jolette Wojdyla, Amruta Poreddy, John Freskos, Raghavan Rajagopalan, Jeng-Jong Shieh, Sevag Demirjian

Proceedings Volume 8596, 85960Z (2013) https://doi.org/10.1117/12.2003078

KEYWORDS: Kidney, Injuries, Plasma, Biomedical optics, Point-of-care devices, Skin, Fiber optics, Systems modeling, In vivo imaging, Analog electronics

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Proceedings Article | 21 February 2012 Paper

Picosecond polarization spectroscopy of fluorescein attached to different molecular volume polymer influenced by rotational motion

Yang Pu, Wubao Wang, R. Dorshow, R. Alfano

Proceedings Volume 8258, 825818 (2012) https://doi.org/10.1117/12.904692

KEYWORDS: Polarization, Luminescence, Picosecond phenomena, Time resolved spectroscopy, Molecules, Anisotropy, Molecular spectroscopy, Polymers, Spectroscopy, Fluorescence spectroscopy

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Proceedings Article | 19 February 2011 Paper

Human skin auto-fluorescence decay as a function of irradiance and skin type

Martin Debreczeny, Rebecca Bates, Rick Fitch, Karen Galen, Jiajia Ge, Richard Dorshow

Proceedings Volume 7897, 78971T (2011) https://doi.org/10.1117/12.875533

KEYWORDS: Skin, Luminescence, Tissue optics, Chromophores, Tissues, Instrument modeling, Fiber optics, Systems modeling, Blood, Blood vessels

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Proceedings Article | 12 February 2011 Paper

Development of fluorescent tracers for the real-time monitoring of renal function

Amruta Poreddy, Bethel Asmelash, Martin Debreczeny, Richard Fitch, John Freskos, Karen Galen, Kimberly Gaston, James Kostelc, Rana Kumar, Tim Marzan, William Neumann, Raghavan Rajagopalan, Tasha Schoenstein, Jeng-Jong Shieh, J. Micah Wilcox, Jolette Wojdyla, Richard Dorshow

Proceedings Volume 7910, 791010 (2011) https://doi.org/10.1117/12.874917

KEYWORDS: Analog electronics, Plasma, In vivo imaging, Proteins, Molecules, Lead, Tissue optics, Luminescence, Blood, In vitro testing

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Proceedings Article | 8 February 2011 Paper

Folate receptor targeted Type 1 photosensitizer bioconjugates for tumor visualization and phototherapy

Raghavan Rajagopalan, Amruta Poreddy, Amolkumar Karwa, Bethel Asmelash, Nicole Putnam, Lori Chinen, Maureen Nichols, J. Jeng Shieh, Richard Dorshow

Proceedings Volume 7886, 78860D (2011) https://doi.org/10.1117/12.875166

KEYWORDS: Receptors, Photosensitizer targeting, Confocal microscopy, Cancer, Sensors, Tumors, Ovarian cancer, Photodynamic therapy, Phototherapy, In vitro testing

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Proceedings Article | 3 March 2010 Paper

In vitro biological effects of novel type I photosensitizers and their mechanism of action

Amolkumar Karwa, Raghavan Rajagopalan, Amruta Poreddy, Carolyn Sympson, Gary Cantrell, Richard Dorshow

Proceedings Volume 7551, 75510S (2010) https://doi.org/10.1117/12.844971

KEYWORDS: Cell death, Ultraviolet radiation, Oxygen, Photodynamic therapy, In vitro testing, Phototherapy, Luminescence, Chemistry, Lamps, Visible radiation

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Proceedings Article | 3 March 2010 Paper

Novel visible light activated type 1 photosensitizers

Raghavan Rajagopalan, Amolkumar Karwa, Amruta Poreddy, Przemyslaw Lusiak, Raghoottama Pandurangi, Gary Cantrell, Richard Dorshow

Proceedings Volume 7551, 75510R (2010) https://doi.org/10.1117/12.844970

KEYWORDS: Visible radiation, Photodynamic therapy, Leukemia, Oxygen, Control systems, Tumors, Phototherapy, Cell death, Ultraviolet radiation, In vitro testing

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Proceedings Article | 13 July 2009 Paper

Novel type 1 photosensitizers: viability of leukemia cells exposed to reactive intermediates generated in situ by in vitro photofragmentation

Raghavan Rajagopalan, Amol Karwa, Przemyslaw Lusiak, Kripa Srivastava, Amruta Poreddy, Raghootama Pandurangi, Karen Galen, William Neumann, Gary Cantrell, Richard Dorshow

Proceedings Volume 7380, 738027 (2009) https://doi.org/10.1117/12.822840

KEYWORDS: Leukemia, Photodynamic therapy, In vitro testing, Oxygen, Cell death, Tumors, Photosensitizer targeting, Phototherapy, Control systems, Ultraviolet radiation

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Proceedings Article | 21 February 2009 Paper

N-alkylated aminopyrazines for use as hydrophilic optical agents

Amruta Poreddy, Bethel Asmelash, Karen Galen, Richard Fitch, Jeng-Jong Shieh, James Wilcox, Tasha Schoenstein, Jolette Wojdyla, Kimberly Gaston, John Freskos, William Neumann, Raghavan Rajagopalan, Hyo-Yang Ahn, James Kostelc, Martin Debreczeny, Kevin Belfield, Richard Dorshow

Proceedings Volume 7190, 71900P (2009) https://doi.org/10.1117/12.809287

KEYWORDS: Plasma, Luminescence, Proteins, Absorption, Tissue optics, In vivo imaging, Molecules, Ear, Kidney, Blood

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Proceedings Article | 22 February 2008 Paper

Fluorescence-enhanced europium complexes for the assessment of renal function

Lori Chinen, Karen Galen, K. Kuan, Mary Dyszlewski, Hiroaki Ozaki, Hiroaki Sawai, Raghootama Pandurangi, Frederick Jacobs, Richard Dorshow, Raghavan Rajagopalan

Proceedings Volume 6867, 68670B (2008) https://doi.org/10.1117/12.763665

KEYWORDS: Europium, Luminescence, Metals, Kidney, Fluorescence resonance energy transfer, Tissues, Antennas, Blood, Forward error correction, Liver

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Proceedings Article | 22 February 2008 Paper

New optical probes for continuous monitoring of renal function

Richard Dorshow, Bethel Asmelash, Lori Chinen, Martin Debreczeny, Richard Fitch, John Freskos, Karen Galen, Kimberly Gaston, Timothy Marzan, Amruta Poreddy, Raghavan Rajagopalan, Jeng-Jong Shieh, William Neumann

Proceedings Volume 6867, 68670C (2008) https://doi.org/10.1117/12.763697

KEYWORDS: Plasma, Luminescence, Proteins, Molecules, In vivo imaging, Blood, Ear, Fluorescence spectroscopy, Synthetic aperture radar, Veins

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Proceedings Article | 4 April 2005 Paper

Unexpected long-term stability of a cyanine dye bioconjugate

Richard Dorshow, Raghavan Rajagopalan

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.590506

KEYWORDS: Blood, Luminescence, Tumors, Near infrared, Optical imaging, Glasses, Charge-coupled devices, Receptors, In vivo imaging, Fluorescence spectroscopy

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Proceedings Article | 14 June 2004 Paper

Targeting the expression of integrin receptors in tumors

Sharon Bloch, Kexian Liang, Richard Dorshow, Yunpeng Ye, Samuel Achilefu

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.533160

KEYWORDS: Tumors, Receptors, Near infrared, Tissues, Liver, Kidney, Pancreas, Optical imaging, Blood, Lung cancer

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Proceedings Article | 2 July 2001 Paper

Targeted Type 1 phototherapeutic agents using azido-peptide bioconjugates

Raghavan Rajagopalan, Samuel Achilefu, Hermo Jimenez, Elizabeth Webb, Michelle Schmidt, Joseph Bugaj, Richard Dorshow

Proceedings Volume 4259, (2001) https://doi.org/10.1117/12.432494

KEYWORDS: Receptors, Tissue optics, Phototherapy, Oxygen, Tumors, Energy transfer, Solids, Near infrared, Lung cancer, Tissues

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Proceedings Article | 2 July 2001 Paper

New approach to optical imaging of tumors

Samuel Achilefu, Joseph Bugaj, Richard Dorshow, Hermo Jimenez, Raghavan Rajagopalan

Proceedings Volume 4259, (2001) https://doi.org/10.1117/12.432489

KEYWORDS: Tumors, Receptors, In vivo imaging, Optical imaging, Tissues, Luminescence, Solids, Molecules, Animal model studies, Tumor growth modeling

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SPIE Journal Paper | 1 April 2001 Open Access

Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform

Joseph Bugaj, Samuel Achilefu, Richard Dorshow, Raghavan Rajagopalan

JBO, Vol. 6, Issue 02, (April 2001) https://doi.org/10.1117/12.10.1117/1.1352748

KEYWORDS: Tumors, Receptors, Luminescence, Tissues, In vivo imaging, Optical imaging, Solids, Tissue optics, Liver, Animal model studies

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Proceedings Article | 31 January 2001 Paper

Site-specific tumor-targeted fluorescent contrast agents

Samuel Achilefu, Joseph Bugaj, Richard Dorshow, Hermo Jimenez, Raghavan Rajagopalan, R. Randy Wilhelm, Elizabeth Webb, Jack Erion

Proceedings Volume 4156, (2001) https://doi.org/10.1117/12.413736

KEYWORDS: Tumors, Receptors, Tissues, In vivo imaging, Solids, Luminescence, In vitro testing, Molecules, Cancer, Blood

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Proceedings Article | 26 April 2000 Paper

Polyionic fluorescent bioconjugates as tracer agents for continuous monitoring of renal function

Raghavan Rajagopalan, Joseph Bugaj, Richard Dorshow, C. Venkatramani, Pamela Uetrecht, Samuel Achilefu

Proceedings Volume 3924, (2000) https://doi.org/10.1117/12.384250

KEYWORDS: Blood, Sodium, Molecules, Micro optical fluidics, Kidney, Chlorine, Time metrology, Medium wave, Luminescence, Liver

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Proceedings Article | 19 April 2000 Paper

Tumor-specific fluorescent contrast agents

Samuel Achilefu, Richard Dorshow, Joseph Bugaj, Raghavan Rajagopalan

Proceedings Volume 3917, (2000) https://doi.org/10.1117/12.382718

KEYWORDS: Tumors, Receptors, Solids, In vivo imaging, Liver, Luminescence, Tissues, Inflammation, Target detection, Optical imaging

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Proceedings Article | 2 July 1999 Paper

Time-resolved fluorescence polarization dynamics and imaging of fluorescein dye attached to different molecular weight chains

Wubao Wang, J. Ali, Richard Dorshow, Margaret McLoughlin, Robert Alfano

Proceedings Volume 3600, (1999) https://doi.org/10.1117/12.351036

KEYWORDS: Polarization, Polymers, Time resolved spectroscopy, Tissues, Scattering media, Visibility, Molecules, Picosecond phenomena, Ultrafast laser spectroscopy, Molybdenum

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Proceedings Article | 17 May 1999 Paper

Monitoring physiological function by detection of exogenous fluorescent contrast agents

Richard Dorshow, Joseph Bugaj, Samuel Achilefu, Raghavan Rajagopalan, Arthur Combs

Proceedings Volume 3599, (1999) https://doi.org/10.1117/12.348383

KEYWORDS: Luminescence, Fiber optics, Fluorescence spectroscopy, Blood, Ear, In vivo imaging, Veins, In vitro testing, Chlorine, Indocyanine green

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SPIE Journal Paper | 1 July 1998 Open Access

Noninvasive fluorescence detection of hepatic and renal function

Richard Dorshow, Joseph Bugaj, B. Burleigh, James Duncan, Michael Johnson, William Jones

JBO, Vol. 3, Issue 03, (July 1998) https://doi.org/10.1117/12.10.1117/1.429854

KEYWORDS: Luminescence, Liver, Fluorescence spectroscopy, In vivo imaging, Ear, Signal detection, Blood, Kidney, Systems modeling, Sensors

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Proceedings Article | 19 June 1998 Paper

Noninvasive fluorescence detection of physiological function

Richard Dorshow, Joseph Bugaj

Proceedings Volume 3252, (1998) https://doi.org/10.1117/12.311887

KEYWORDS: Liver, Luminescence, In vivo imaging, Ear, Fluorescence spectroscopy, Signal detection, Fiber optics, Blood, Data modeling, Kidney

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Showing 5 of 31 publications

Conference Committee Involvement (17)

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII

6 March 2021 | Online Only, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII

4 February 2020 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI

4 February 2019 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X

29 January 2018 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX

30 January 2017 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII

15 February 2016 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII

9 February 2015 | San Francisco, California, United States