James Montgomery, Michael Wesolowski, Bailey Wolkowski, Rajni Chibbar, Elisabeth C. Snead, Jaswant Singh, Murray Pettitt, Pritpal Malhi, Trinita Barboza, Gregg Adams
Journal of Medical Imaging, Vol. 3, Issue 01, 015504, (March 2016) https://doi.org/10.1117/1.JMI.3.1.015504
TOPICS: Tissues, X-ray imaging, X-rays, Synchrotrons, Phase contrast, Prostate, Tumors, Synchrotron x-ray imaging, Medicine, Diagnostics
Prostatic urethral transitional cell carcinoma with prostatic invasion in a dog was imaged with abdominal radiography and abdominal ultrasonography antemortem. Synchrotron in-line x-ray phase contrast imaging computed tomography (XPCI-CT) was performed on the prostate ex vivo at the Canadian Light Source Synchrotron and compared to histology. XPCI-CT imaging provides greater soft tissue contrast than conventional absorption-based x-ray imaging modalities, permitting visualization of regions of inflammatory cell infiltration, differentiation of invasive versus noninvasive tumor regions, and areas of necrosis and mineralization. This represents the first report of XPCI-CT images of an invasive prostatic urothelial neoplasm in a dog.