The non-selective beta-blocker timolol has shown promising evidence for healing chronic, recalcitrant wounds, improving scar cosmesis, and expediting the completion of secondary intention. The purpose of our pilot study is to use clinical imaging, two-photon excitement fluorescence (TPF) and second harmonic generation (SHG) microscopy to evaluate the temporal and molecular effects of timolol vs. normal saline in Sprague-Dawley rats traumatized by 5-millimeter dermal punch biopsy. Initial findings suggest timolol delays wound contraction, but advanced imaging techniques may reveal novel collagenous or vascular mechanisms by which timolol is affecting acute wound healing.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.