Mr. Andrey V. Terskov Profile

Andrey V. Terskov

at Saratov State Univ

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Author

Publications (9)

Proceedings Article | 9 April 2020 Paper

Synchronization of cerebral and peripheral blood circulation: stress-induced changes

Andrey Terskov, Olga Pavlova, Arkady Abdurashitov, Alexey Pavlov, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11459, 114590R (2020) https://doi.org/10.1117/12.2559692

KEYWORDS: Blood circulation, Neck, Oscillators, Veins, Wavelets, Continuous wavelet transforms, Speckle

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Proceedings Article | 6 March 2020 Presentation

Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer’s disease (Conference Presentation)

Oxana Semyachkina-Glushkovskaya, Ekaterina Zinchenko, Maria Klimova, Andrey Terskov, Arkady Abdurashitov, Alexander Dubrovsky, Inna Blokhina, Alexander Khorovodov, Ilana Agranovich, Nikita Navolokin, Alexander Shirokov, Elena Saranceva, Aysel Mamedova, Valery Tuchin, Juergen Kurths

Proceedings Volume 11241, 1124103 (2020) https://doi.org/10.1117/12.2541561

KEYWORDS: Brain, Alzheimer's disease, Lymphatic system, Optical coherence tomography, Confocal microscopy, Gold, Nanorods, Neck

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Proceedings Article | 3 June 2019 Paper

The role of the meningeal lymphatic in the brain clearing

M. Klimova , A. Dubrovsky, E. Duarte Torres , A. Abdurashitov, A. Shirokov, A. Terskov, A. Khorovodov, E. Sarantseva, T. Iskra, O. Semyachkina-Glushkovskaya

Proceedings Volume 11067, 110670Z (2019) https://doi.org/10.1117/12.2524451

KEYWORDS: Neuroimaging, Tomography, Nanorods, Tissues, In vivo imaging, Confocal microscopy, Optical coherence tomography, Blood brain barrier, Brain, Lymphatic system

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Proceedings Article | 3 June 2019 Paper

5-ALA/PpIX fluorescent diagnostics of stressed-induced small and large intestine neoplasia in laboratorial rats in vivo

Ekaterina Borisova, Alexander Khorovodov, Ilana Agranovich, Aysel Mamedova, Andrey Terskov, Mikita Navolokin, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11065, 1106504 (2019) https://doi.org/10.1117/12.2523945

KEYWORDS: Tumor growth modeling, Colon, Spectroscopy, Stomach, Cancer, Tissue optics, Diagnostics, Luminescence, Intestine, Tissues

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Proceedings Article | 3 June 2019 Paper

Diagnostic of gastric pre-cancer with complexity analysis

Alexey Pavlov, Ekaterina Borisova, Olga Pavlova, Ilana Agranovich, Alexander Khorovodov, Andrey Terskov, Aysel Mamedova, Maria Klimova, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11067, 110670K (2019) https://doi.org/10.1117/12.2522421

KEYWORDS: Data processing, Stomach, Animal model studies, Tumors, Diagnostics, Cancer

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Proceedings Article | 4 March 2019 Presentation + Paper

Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance

O. Semyachkina-Glushkovskaya, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Terskov, A. Mamedova, A. E. Shareef, E. Saranceva, T. Iskra, A. Pavlov, J. Kurths

Proceedings Volume 10879, 108790C (2019) https://doi.org/10.1117/12.2508259

KEYWORDS: Brain, Blood brain barrier, Laser therapeutics, Receptors, Tissues

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Proceedings Article | 1 March 2019 Paper

Entrainment between the dynamics of cerebral and peripheral blood flow characterized by wavelet coherence

Olga Pavlova, Arkady Abdurashitov, Andrey Terskov, Oxana Semyachkina-Glushkovskaya, Alexey Pavlov

Proceedings Volume 10877, 1087711 (2019) https://doi.org/10.1117/12.2511409

KEYWORDS: Blood circulation, Neck, Veins, Wavelets, Speckle, Arteries, Cerebral blood flow, Blood vessels, Complex systems

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Proceedings Article | 1 March 2019 Presentation + Paper

Lymphatic clearance from the blood after subarachnoid hemorrhages

O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Dubrovsky, A. Shirokov, N. Navolokin, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Mamedova, A. E. Shareef, A. Terskov, E. Saranceva, T. Iskra, J. Kurths

Proceedings Volume 10865, 108650T (2019) https://doi.org/10.1117/12.2509065

KEYWORDS: Lymphatic system, Blood, Brain, Optical coherence tomography, Blood brain barrier, Statistical analysis, Absorption spectroscopy, Tomography

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Proceedings Article | 29 January 2019 Paper

Stomach and intestine neoplasia fluorescence detection using 5-ALA/PpIX photosensitization

Ekaterina Borisova, Tsanislava Genova, Alexabder Khorovodov, Andrey Terskov, Matvey Kanevsky, Alexander Gisbrecht, Latchezar Avramov, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11047, 1104708 (2019) https://doi.org/10.1117/12.2516338

KEYWORDS: Cancer, Endoscopy, Algorithm development, Fluorescence spectroscopy, Diagnostics, Tumors, Intestine, Stomach, Tissues, Luminescence

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In the recent study delta-ALA/PpIX is used as fluorescent marker for tumor detection in stomach, small intestine and colon. 5-ALA was administered per os two hours before measurements at dose 20 mg/kg weight. Twenty laboratorial rats with developed neoplasia in gastrointestinal tract were used. Three of them formed control group - without application of exogenous 5-ALA/PpIX, as a contrast fluorescent marker. Their spectral properties were evaluated and used for correction of endogenous sources of fluorescence from stomach and intestine lesions detected. Macroscopic fluorescence spectroscopy parameters of gastrointestinal tissues of the other 17 animals, which were sensitized with 5- ALA?PpIX, were obtained on excitation at 405 nm. Excitation and emission light was delivered by fiberoptic probe 6+1 to the organs investigated in vivo during open surgery procedure on the laboratorial animals used. The fluorescence detected from tumor sites has very complex spectral origins. It consists of autofluorescence, fluorescence from exogenous fluorophores and re-absorption from the chromophores accumulated in the tissue investigated. Spectral features observed during endoscopic investigations could be distinct as the next regions: 450-630 nm region, where tissue autofluorescence is observed; 630-710 nm region, where fluorescence of PpIX is clearly pronounced; 530-580 nm region, where minima in the autofluorescence signal are observed, related to re-absorption of oxy-hemoglobin in this spectral area. The contrast achieved in normal vs. neoplastic gastrointestinal tissues was evaluated. Influence of endogenous 5-ALA/PpIX accumulation was taken into account; as well the role of inflammatory processes on the PpIX distribution and accumulation into the body was evaluated. Dimensionless ratio R=I₆₃₅/I₅₆₀ is evaluated as highly informative one for development of a simple algorithm for differentiation, which could has high diagnostic accuracy for evaluation of tumor vs. inflammatory vs. normal mucosa, using 1-D spectral results. Very good correlation between fluorescence data and histology examination of the lesions investigated was achieved as well.

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