Colorectal cancer (CRC) ranks third globally in terms of prevalence, accounting for 10% of cancer cases and deaths each year. Irreversible electroporation (IRE) offers promise for treating CRC by selectively destroying tumor cells while minimizing harm to healthy tissue. However, the lack of effective guidance and evaluation methods hampers the achievement of complete tumor ablation. To address this, integrated OCT, US, and NIRF endoscopy enable real-time imaging of colorectal tumors, facilitating precise IRE treatment and evaluation of outcomes. In this study, we used an integrated imaging system to precisely guide and evaluate the implementation of IRE therapy in CRC.
In-stent restenosis (ISR) and its associated inflammation remains a significant concern for long-term patient outcomes following stent implantation in percutaneous coronary intervention (PCI). The problem is intricately associated with endothelial injury, excessive endothelialization, hyperproliferation of smooth muscle cells, and the infiltration of inflammatory molecules. However, commonly employed imaging techniques encounter challenges in simultaneously acquiring both vascular structural information and functional data related to inflammation. Here, we presented a novel Tri modality intravascular imaging system capable of simultaneous optical coherence tomography (OCT), near-infrared fluorescence (NIRF), ultrasound (US) imaging, and fabricated the OCT-NIRF-US catheter which outer diameter is 0.75 mm, aiming to provide a more comprehensive diagnostic tool for ISR and its associated inflammation. Experiments were conducted on atherosclerotic rabbits implanted with a scaffold, divided into two groups (n=3 each group) for assessment on the first and twenty-eighth day, respectively. Primary results demonstrated that the integrated OCT-NIRF-US intravascular system enables complementary structural imaging and functional imaging of inflammation. The system presents the potential to offer a more accurate assessment, providing with valuable insights into the ISR processing and assisting in the development of more precise clinical strategies.
In the last decade, there has been a growing interest in dual-modality imaging techniques that combine intravascular ultrasound (IVUS) with optical coherence tomography (OCT) for intravascular imaging. However, accurately quantifying the vulnerability of coronary atherosclerotic plaques solely through structural imaging methods remains challenging. Optical Coherence Elastography (OCE) technology, which assesses tissue elasticity by analyzing tissue displacement and strain distribution, has emerged as a promising approach. In recent years, the field of intravascular optical coherence elastography has shown significant progress, and its potential applications are becoming increasingly evident. In this study, we developed a comprehensive imaging system capable of IVUS-OCT-OCE tri-modality imaging for both phantom and biological tissues. Preliminary results indicate that the system exhibits high-quality imaging capabilities and offers precise identification of plaque tissue. This presents a novel approach for characterizing plaque tissue within blood vessels and holds promise for early diagnosis in coronary atherosclerosis
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