This course will provide attendees with a basic working knowledge of methods used to register images, and a description of some examples of the wide variety of applications for which these techniques are used. Applications of image registration include combining images of the same subject from different modalities, aligning temporal sequences of images to compensate for motion of the subject between scans, providing guidance during surgical procedures, correcting for soft tissue deformation, and aligning images from multiple subjects in cohort studies. Current registration algorithms can in many cases automatically register images that are related by a rigid-body transformation. There has also been substantial progress in non-rigid registration algorithms that can compensate for tissue deformation or align images from different subjects.