Optical coherence microscopy (OCM) captures the optical field with high sensitivity and thus enables computational wavefront retrieval. Compared to a real-time wavefront sensor, wavefront measurement with OCM in post-processing uses coherence and confocal gate to obtain signals with less spatial crosstalk. Also, since this approach only requires a single shot, it is more robust to in vivo sample motion than sensorless adaptive optics. By computational aberration sensing and hardware correction, we demonstrated a physical compensation of the intentionally induced aberration at the white matter layer (~900 μm) in an ex vivo mouse brain.
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