I am a Ph.D. candidate in the F. Joseph Halcomb III, M.D. Department of Biomedical Engineering (BME), and has been awarded a Predoctoral Fellowship by the American Heart Association (AHA) in 2021 to continue my research project titled “Mapping Brain Functional Connectivity Using Speckle Contrast Diffuse Correlation Tomography (scDCT).”
I am working on the development of a speckle contrast diffuse correlation tomography (scDCT) system to measure the 3D imaging of cerebral blood flow (CBF) distribution in perinatal disease models. Our results showed that scDCT is able to effectively identify brain hemodynamic disruptions, like CBF reduction. We used neonatal piglets to evaluate the scDCT system. In particular, the transient global ischemia was induced in one neonatal piglet, an intraventricular hemorrhage was stimulated in another piglet, and a hypoxic challenge was administered to instigate perinatal asphyxia in the piglets after CBF was reestablished. The scDCT system was used to determine CBF during global ischemia, intraventricular hemorrhage, and asphyxia, and also produce 3D images of blood flow distributions. Our innovative scDCT was tested in a rat model of transient ischemic stroke. Ischemic stroke may result in cerebral injury, neurologic deficit, and disrupted cerebral functional connectivity.
I am working on mapping Resting-state functional connectivity (RSFC) using scDCT data. RSFC is assessed by imaging of spontaneous LFOs over brain neurovascular networks. The feasibility of scDCT for noninvasive detection of LFOs alteration and RSFC disruption after transient ischemic stroke is demonstrated.
The scDCT system importantly addresses the need for a portable, bedside neuroimaging technology that is capable of continuously measuring CBF and brain function alterations, thereby enabling the evaluation of brain health and the improvement of clinical decisions and outcomes in critically ill newborn infants.
I am working on the development of a speckle contrast diffuse correlation tomography (scDCT) system to measure the 3D imaging of cerebral blood flow (CBF) distribution in perinatal disease models. Our results showed that scDCT is able to effectively identify brain hemodynamic disruptions, like CBF reduction. We used neonatal piglets to evaluate the scDCT system. In particular, the transient global ischemia was induced in one neonatal piglet, an intraventricular hemorrhage was stimulated in another piglet, and a hypoxic challenge was administered to instigate perinatal asphyxia in the piglets after CBF was reestablished. The scDCT system was used to determine CBF during global ischemia, intraventricular hemorrhage, and asphyxia, and also produce 3D images of blood flow distributions. Our innovative scDCT was tested in a rat model of transient ischemic stroke. Ischemic stroke may result in cerebral injury, neurologic deficit, and disrupted cerebral functional connectivity.
I am working on mapping Resting-state functional connectivity (RSFC) using scDCT data. RSFC is assessed by imaging of spontaneous LFOs over brain neurovascular networks. The feasibility of scDCT for noninvasive detection of LFOs alteration and RSFC disruption after transient ischemic stroke is demonstrated.
The scDCT system importantly addresses the need for a portable, bedside neuroimaging technology that is capable of continuously measuring CBF and brain function alterations, thereby enabling the evaluation of brain health and the improvement of clinical decisions and outcomes in critically ill newborn infants.
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