Modern noninvasive imaging techniques are used in many areas of medical research, particularly where an additional modality is required to support close monitoring during pre- or post-care. In oral medicine, the combination of an experienced clinician and supporting noninvasive optical devices for oral imaging, such as optical coherence tomography (OCT), may ensure improved diagnosis. In this study, the pathological features of lichenoid oral mucosa were noninvasively imaged with our miniaturized pen-like OCT probe and compared to adjacent healthy areas. The non-homogeneous epithelial (EP) layer, increased cornification of the EP surface and unidentifiable basement membrane are the most important features recorded.
We present a miniaturized handheld OCT probe (9 grams weight), approximately the size of a small pen (10 mm x 140 mm), developed for use inside a patient’s mouth for examination of the oral mucosa. The probe operates in common-path mode and uses a magnetic scanning system to actuate a lensed fibre, achieving 50 B-scans per second. The system is demonstrated with OCT imaging of the buccal and alveolar mucosa of six patients with oral lichen planus (OLP) during clinical routine examination, and showed pathological changes in the tissue microarchitecture.
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