Dr. Robert C. Molthen Profile

Dr. Robert C. Molthen

Lead Coil Integrator

SPIE Involvement:

Author | Editor

Area of Expertise:

Medical Imaging , MR Coils Integration , Pulmonary Hypertension , Pulmonary Vascular Remodleing , Small Animal Imaging , Radiation Injury

Websites:

Company Website

Proceedings Article | 3 March 2017 Presentation + Paper

Classification of micro-CT images using 3D characterization of bone canal patterns in human osteogenesis imperfecta

Anas Abidin, John Jameson, Robert Molthen, Axel Wismüller

Proceedings Volume 10134, 1013413 (2017) https://doi.org/10.1117/12.2254421

KEYWORDS: Binary data, Computer aided diagnosis and therapy, Biological research, Bone, 3D image processing, Image classification, Image resolution, Computed tomography, Tomography

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Proceedings Article | 9 March 2011 Paper

Micro-CT characterization of human trabecular bone in osteogenesis imperfecta

John Jameson, Carolyne Albert, Peter Smith, Robert Molthen, Gerald Harris

Proceedings Volume 7965, 79650I (2011) https://doi.org/10.1117/12.877586

KEYWORDS: Bone, Minerals, Genetics, Collagen, Tissues, Dual energy x-ray absorptiometry, Reconstruction algorithms, Magnesium, Tomography, Image analysis

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Proceedings Article | 9 March 2010 Paper

Arterial morphology responds differently to Captopril then N-acetylcysteine in a monocrotaline rat model of pulmonary hypertension

Robert Molthen, Qingping Wu, Shelley Baumgardt, Laura Kohlhepp, Rahul Shingrani, Gary Krenz

Proceedings Volume 7626, 762615 (2010) https://doi.org/10.1117/12.844830

KEYWORDS: Lung, Control systems, Arteries, Pulmonary hypertension, Data modeling, Heart, Detection and tracking algorithms, Angiography, Blood, Resistance

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Proceedings Article | 9 March 2010 Paper

The effect of ACE inhibition on the pulmonary vasculature in combined model of chronic hypoxia and pulmonary arterial banding in Sprague Dawley rats

Shanelle Clarke, Shelley Baumgardt, Robert Molthen

Proceedings Volume 7626, 762614 (2010) https://doi.org/10.1117/12.846387

KEYWORDS: Lung, Hypoxia, Arteries, Hemodynamics, Computed tomography, Resistance, Data modeling, Pulmonary hypertension, Angiography, Heart

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Microfocal CT was used to image the pulmonary arterial (PA) tree in rodent models of pulmonary hypertension (PH). CT images were used to measure the arterial tree diameter along the main arterial trunk at several hydrostatic intravascular pressures and calculate distensibility. High-resolution planar angiographic imaging was also used to examine distal PA microstructure. Data on pulmonary artery tree morphology improves our understanding of vascular remodeling and response to treatments. Angiotensin II (ATII) has been identified as a mediator of vasoconstriction and proliferative mitotic function. ATII has been shown to promote vascular smooth muscle cell hypertrophy and hyperplasia as well as stimulate synthesis of extracellular matrix proteins. Available ATII is targeted through angiotensin converting enzyme inhibitors (ACEIs), a method that has been used in animal models of PH to attenuate vascular remodeling and decrease pulmonary vascular resistance. In this study, we used rat models of chronic hypoxia to induce PH combined with partial left pulmonary artery occlusion (arterial banding, PLPAO) to evaluate effects of the ACEI, captopril, on pulmonary vascular hemodynamic and morphology. Male Sprague Dawley rats were placed in hypoxia (FiO2 0.1), with one group having underwent PLPAO three days prior to the chronic hypoxia. After the twenty-first day of hypoxia exposure, treatment was started with captopril (20 mg/kg/day) for an additional twenty-one days. At the endpoint, lungs were excised and isolated to examine: pulmonary vascular resistance, ACE activity, pulmonary vessel morphology and biomechanics. Hematocrit and RV/LV+septum ratio was also measured. CT planar images showed less vessel dropout in rats treated with captopril versus the non-treatment lungs. Distensibility data shows no change in rats treated with captopril in both chronic hypoxia (CH) and CH with PLPAO (CH+PLPAO) models. Hemodynamic measurements also show no change in the pulmonary vascular resistance with captopril treatment in both CH and CH+PLPAO.

Proceedings Article | 28 February 2009 Paper

Imaging radiation pneumonitis in a rat model of a radiological terrorism incident

Robert Molthen, QingPing Wu, Gary Krenz, Meetha Medhora, Elizabeth Jacobs, John Moulder

Proceedings Volume 7262, 72620X (2009) https://doi.org/10.1117/12.810935

KEYWORDS: Lung, Control systems, Injuries, Binary data, Arteries, Angiography, Resistance, Visualization, X-ray imaging, Radiation injury

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Proceedings Article | 30 April 2004 Paper

Changes in pulmonary arterial wall mechanical properties and lumenal architecture with induced vascular remodeling

Robert Molthen, Amy Heinrich, Steven Haworth, Christopher Dawson

Proceedings Volume 5369, (2004) https://doi.org/10.1117/12.535738

KEYWORDS: Lung, Control systems, Arteries, Hemodynamics, Pulmonary hypertension, Genetics, Hypoxia, X-ray imaging, X-rays, X-ray computed tomography

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Proceedings Article | 30 April 2004 Paper

Quantification of bronchial circulation perfusion in rats

Christian Wietholt, Robert Molthen, Steven Haworth, David Roerig, Christopher Dawson, Anne Clough

Proceedings Volume 5369, (2004) https://doi.org/10.1117/12.536814

KEYWORDS: Lung, Single photon emission computed tomography, Arteries, Reconstruction algorithms, Control systems, Image segmentation, Imaging systems, Expectation maximization algorithms, Medical imaging, Cameras

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Proceedings Article | 30 April 2004 Paper

Post-acquisition small-animal respiratory gated imaging using micro cone-beam CT

Jicun Hu, Steven Haworth, Robert Molthen, Christopher Dawson

Proceedings Volume 5369, (2004) https://doi.org/10.1117/12.535900

KEYWORDS: Lung, Gated imaging, Imaging systems, Image processing, Reconstruction algorithms, Physiology, Tomography, Sensors, X-ray computed tomography, Computed tomography

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Proceedings Article | 2 May 2003 Paper

SPECT imaging of pulmonary blood flow in a rat

Christian Wietholt, Robert Molthen, Roger Johnson, Christopher Dawson, Anne Clough

Proceedings Volume 5031, (2003) https://doi.org/10.1117/12.485802

KEYWORDS: Single photon emission computed tomography, Lung, Data acquisition, Blood circulation, Reconstruction algorithms, Signal to noise ratio, Cameras, Image fusion, Imaging systems, Collimators

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Proceedings Article | 2 May 2003 Paper

Measuring the effect of airway pressure on pulmonary arterial diameter in the intact rat lung

Robert Molthen, Steven Haworth, Amy Heinrich, Christopher Dawson

Proceedings Volume 5031, (2003) https://doi.org/10.1117/12.485800

KEYWORDS: Lung, Arteries, Computed tomography, Imaging systems, X-rays, Physiology, Preclinical imaging, Data acquisition, Angiography, Ranging

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Proceedings Article | 24 April 2002 Paper

Estimation of pulmonary arterial volume changes in the normal and hypertensive fawn-hooded rat from 3D micro-CT data

Robert Molthen, Christian Wietholt, Steven Haworth, Christopher Dawson

Proceedings Volume 4683, (2002) https://doi.org/10.1117/12.463592

KEYWORDS: Lung, Arteries, Calibration, Hypoxia, X-ray computed tomography, X-rays, Genetics, X-ray imaging, Blood, Binary data

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Proceedings Article | 21 May 2001 Paper

Pulmonary arterial remodeling revealed by microfocal x-ray tomography

Kelly Karau, Robert Molthen, Roger Johnson, Anita Dhyani, Steven Haworth, Christopher Dawson

Proceedings Volume 4321, (2001) https://doi.org/10.1117/12.428147

KEYWORDS: Lung, Resistance, Image intensifiers, X-rays, Hemodynamics, X-ray imaging, Image segmentation, Arteries, Floods, Tomography

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Proceedings Article | 21 May 2001 Paper

Semiautomated skeletonization of the pulmonary arterial tree in micro-CT images

Christopher Hanger, Steven Haworth, Robert Molthen, Christopher Dawson

Proceedings Volume 4321, (2001) https://doi.org/10.1117/12.428181

KEYWORDS: Lung, 3D image processing, Image intensifiers, X-ray sources, X-rays, Polonium, Physiology, Image segmentation, Arteries, Biomedical engineering

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Proceedings Article | 20 April 2000 Paper

Micro-CT image-derived metrics quantify arterial wall distensibility reduction in a rat model of pulmonary hypertension

Roger Johnson, Kelly Karau, Robert Molthen, Steven Haworth, Christopher Dawson

Proceedings Volume 3978, (2000) https://doi.org/10.1117/12.383413

KEYWORDS: Lung, Image segmentation, Pulmonary hypertension, Point spread functions, Arteries, 3D metrology, 3D image processing, Animal model studies, Scanners, 3D modeling

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Proceedings Article | 22 September 1999 Paper

Quantification of pulmonary arterial wall distensibility using parameters extracted from volumetric micro-CT images

Roger Johnson, Kelly Karau, Robert Molthen, Christopher Dawson

Proceedings Volume 3772, (1999) https://doi.org/10.1117/12.363721

KEYWORDS: Lung, Image segmentation, X-rays, Pulmonary hypertension, Mercury, Arteries, X-ray imaging, Data acquisition, Sensors, 3D image processing

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Proceedings Article | 20 May 1999 Paper

Exploiting self-similarity of arterial trees to reduce the complexity of analysis

Roger Johnson, Kelly Karau, Robert Molthen, Christopher Dawson

Proceedings Volume 3660, (1999) https://doi.org/10.1117/12.349605

KEYWORDS: Lung, Image segmentation, 3D image processing, Sensors, Image intensifiers, Image analysis, Statistical analysis, Imaging systems, Image processing, 3D metrology

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Showing 5 of 16 publications

SPIE Conference Volume | 14 May 2015

Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging

SPIE Conference Volume | 18 April 2014

Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging

SPIE Conference Volume | 16 April 2013

Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging

SPIE Conference Volume | 25 April 2012

Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging

SPIE Conference Volume | 4 March 2011

Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging

Showing 5 of 6 publications

Conference Committee Involvement (16)