Prof. Sehyun Shin Profile

Prof. Sehyun Shin

at Korea Univ

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Publications (7)

Proceedings Article | 3 June 2019 Paper

Red blood cells interaction mediated by dextran macromolecules: in vitro study using diffuse light scattering technique and optical tweezers

Alexey Semenov, Andrei Lugovtsov, Sehyun Shin, Gregory Barshtein, Alexander Priezzhev

Proceedings Volume 11065, 110651X (2019) https://doi.org/10.1117/12.2523744

KEYWORDS: Blood, Optical tweezers, Polymers, Light scattering, Macromolecules, Molecules, In vitro testing, Calibration

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Proceedings Article | 9 March 2016 Paper

Study of erythrocyte membrane fluctuation using light scattering analysis

Hoyoon Lee, Sangyun Lee, YongKeun Park, Sehyun Shin

Proceedings Volume 9718, 971818 (2016) https://doi.org/10.1117/12.2210777

KEYWORDS: Light scattering, Blood, Diagnostics, Spatial frequencies, Statistical analysis, Diffraction, Image sensors, Picosecond phenomena, Scattering, Biomedical optics

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SPIE Journal Paper | 1 March 2010 Open Access

Comparison of light-transmission and -backscattering methods in the measurement of red blood cell aggregation

Jeong-Hun Nam, Yijie Yang, Seok Chung, Sehyun Shin

JBO, Vol. 15, Issue 02, 027003, (March 2010) https://doi.org/10.1117/12.10.1117/1.3365951

KEYWORDS: Backscatter, Blood, Artificial intelligence, Polarizers, Polarization, Laser optics, Light scattering, Multiple scattering, Photodiodes, Semiconductor lasers

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Proceedings Article | 25 February 2006 Paper

Early diagnosis of diabetic vascular complications: impairment of red blood cell deformability

Sehyun Shin, Yunhee Ku, Cheol-Woo Park, Jang-Soo Suh

Proceedings Volume 6080, 608014 (2006) https://doi.org/10.1117/12.657383

KEYWORDS: Blood, Diffraction, Protactinium, CCD cameras, Semiconductor lasers, Liquids, Cameras, Pathogens, Chemical elements, Kidney

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Reduced deformability of red blood cells (RBCs) may play an important role on the pathogenesis of chronic vascular complications of diabetes mellitus. However, available techniques for measuring RBC deformability often require washing process after each measurement, which is not optimal for day-to-day clinical use at point of care. The objectives of the present study are to develop a device and to delineate the correlation of impaired RBC deformability with diabetic nephropathy. We developed a disposable ektacytometry to measure RBC deformability, which adopted a laser diffraction technique and slit rheometry. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element which is in contact with the blood sample. We studied adult diabetic patients divided into three groups according to diabetic complications. Group I comprised 57 diabetic patients with normal renal function. Group II comprised 26 diabetic patients with chronic renal failure (CRF). Group III consisted of 30 diabetic subjects with end-stage renal disease (ESRD) on hemodialysis. According to the renal function for the diabetic groups, matched non-diabetic groups were served as control. We found substantially impaired red blood cell deformability in those with normal renal function (group I) compared to non-diabetic control (P = 0.0005). As renal function decreases, an increased impairment in RBC deformability was found. Diabetic patients with chronic renal failure (group II) when compared to non-diabetic controls (CRF) had an apparently greater impairment in RBC deformability (P = 0.07). The non-diabetic cohort (CRF), on the other hand, manifested significant impairment in red blood cell deformability compared to healthy control (P = 0.0001). The newly developed slit ektacytometer can measure the RBC deformability with ease and accuracy. In addition, progressive impairment in cell deformability is associated with renal function loss in all patients regardless of the presence or absence of diabetes. In diabetic patients, early impairment in RBC deformability appears in patients with normal renal function.

Proceedings Article | 6 December 2005 Paper

Hemodynamic investigation on blood flow in a rugged microchannel

C. Park, G. Kim, S. Shin, S. Lee, Y. Ku, J. Jang

Proceedings Volume 6050, 60500Y (2005) https://doi.org/10.1117/12.649749

KEYWORDS: Blood circulation, Blood, Velocity measurements, Particles, Microfluidics, Visualization, CCD cameras, Hemodynamics, Spatial resolution, Computing systems

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Proceedings Article | 16 February 2005 Paper

Disposable biosensor for measuring red blood cell deformability using laser-diffraction technique

Sehyun Shin, Yunhee Ku, Myungsu Park, Jangsoo Suh

Proceedings Volume 5651, (2005) https://doi.org/10.1117/12.581265

KEYWORDS: Blood, Diffraction, Protactinium, CCD cameras, Cameras, Semiconductor lasers, Frame grabbers, Biosensors, Control systems, Chemical elements

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Proceedings Article | 18 January 2005 Paper

Disposable laser-diffraction ektacytometry to measure red blood cell deformability

Sehyun Shin, Yunhee Ku, Myungsu Park, Lijuan Zhang, Joohee Jang, Jangsoo Suh

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.575957

KEYWORDS: Diffraction, Blood, Protactinium, CCD cameras, Semiconductor lasers, Cameras, Control systems, Frame grabbers, Data acquisition, Computing systems

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Showing 5 of 7 publications

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