Intense pulsed light (IPL) is an incoherent high intensity pulsed light source and commonly used in dermatology and aesthetics. Early studies suggest that the combination of IPL and photosensitizer can induce cellular phototoxicity. Hemoporfin is a domestic photosensitizer approved for PDT treatment of Portwine stain birthmarks. This in vivo study evaluated the feasibility of using IPL as a light source for the excitation of Hemoporfin in mouse model. Results showed that IPL+Hemoporfin could cause more severe photodamage than IPL alone group, which suggests that it might be feasible to use IPL as PDT light source.
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